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Volume 36 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(3): 247-249,254

MA Huiping, WANG Xin, WU Ningzi, JING Linlin, JIA Zhengping, ZHANG Jun. Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involucrata[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 247-249,254. doi: 10.3969/j.issn.1006-0111.2018.03.012
Citation: MA Huiping, WANG Xin, WU Ningzi, JING Linlin, JIA Zhengping, ZHANG Jun. Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involucrata[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 247-249,254. doi: 10.3969/j.issn.1006-0111.2018.03.012
shu

Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involucrata

doi: 10.3969/j.issn.1006-0111.2018.03.012

  • Lanzhou General Hospital Key Lab of PLA for Prevention and Treatment of Injuries induced by High Altitude, Lanzhou 730050, China

  • Received Date: 2017-11-08
  • Rev Recd Date: 2018-01-18
  • Objective To study pharmacodynamics of the effective anti-hypoxia components in the petroleum ether extract of Saussurea Involucrate (PESI) and octacosane. Methods PESI and octacosane were first evaluated by normobaric hypoxia model, acute decompression model and followed by chemical induced hypoxic models with potassium cyanide, sodium nitrite and isoprenaline hydrochloride poisoning. Results PESI and octacosane can effectively prolong the survival time of hypobaric hypoxic mice (P<0.01) and reduce the mortality of acute hypobaric hypoxia mice (P<0.01) in a dose-dependent manner. Anti-hypoxic potency of PESI and octacosane obtained by chemical induced hypoxic model indicated that they significantly increase survival time(P<0.05)of hypoxia mice than acetazolamide. Conclusion PESI and octacosane have good anti-hypoxia activity.
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    [2] Jia JM,Wu CF,Liu W,et al.Antiinflammatory and analgesic activities of the tissue culture of Saussurea involucrata[J].BiolPharm Bull,2005,28(9):1612-1614.
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    [4] 马慧萍,焦阳,高荣敏,等.大苞雪莲乙醇提取物对模拟高原缺氧小鼠生化指标的影响[J].中药材,2014,37(1):99-103.
    [5] Ma HP,Fan PC,Jing LL,et al.Anti-hypoxic activity at simulated high altitude was isolated in petroleum ether extract of Saussurea involucrata[J].J Ethnopharmacol, 2011, 137(3):1510-1515.
    [6] 景临林,何蕾,樊鹏程,等.天山雪莲抗缺氧活性成分研究[J].中药材,2015,38(1):89-92.
    [7] 马慧萍,何蕾,王昕,等.藏紫菀总黄酮对模拟高原缺氧小鼠的保护作用[J].解放军医药杂志,2016,28(6):1-4.
    [8] 陈奇.中药药理研究方法学[M].北京:人民卫生出版社,2006:63-78.
    [9] 许福会,曾南,彭希,等.芳香开窍药对小鼠急性缺氧损伤的影响[J].中药药理与临床,2010,26(5):72-74.
    [10] 景临林,马慧萍,杨芳芳,等.新型双靶标化合物的合成与其抗高原缺氧损伤活性研究[J].解放军医药杂志, 2016,28(6):5-8,13.
    [11] 马慧萍,高荣敏,吴金华,等.大苞雪莲乙醇提取物对模拟高原缺氧小鼠物质代谢的影响[J].解放军药学学报,2013,29(4):279-282.
    [12] 蒋炜,樊鹏程,何蕾,等.天山雪莲乙醇提取物对缺氧小鼠肝脏线粒体的保护作用研究[J].中药材,2015,38(4):790-793.
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Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involucrata

doi: 10.3969/j.issn.1006-0111.2018.03.012
  • Lanzhou General Hospital Key Lab of PLA for Prevention and Treatment of Injuries induced by High Altitude, Lanzhou 730050, China
  • Received Date: 2017-11-08
  • Rev Recd Date: 2018-01-18

Abstract: Objective To study pharmacodynamics of the effective anti-hypoxia components in the petroleum ether extract of Saussurea Involucrate (PESI) and octacosane. Methods PESI and octacosane were first evaluated by normobaric hypoxia model, acute decompression model and followed by chemical induced hypoxic models with potassium cyanide, sodium nitrite and isoprenaline hydrochloride poisoning. Results PESI and octacosane can effectively prolong the survival time of hypobaric hypoxic mice (P<0.01) and reduce the mortality of acute hypobaric hypoxia mice (P<0.01) in a dose-dependent manner. Anti-hypoxic potency of PESI and octacosane obtained by chemical induced hypoxic model indicated that they significantly increase survival time(P<0.05)of hypoxia mice than acetazolamide. Conclusion PESI and octacosane have good anti-hypoxia activity.

MA Huiping, WANG Xin, WU Ningzi, JING Linlin, JIA Zhengping, ZHANG Jun. Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involucrata[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 247-249,254. doi: 10.3969/j.issn.1006-0111.2018.03.012
Citation: MA Huiping, WANG Xin, WU Ningzi, JING Linlin, JIA Zhengping, ZHANG Jun. Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involucrata[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 247-249,254. doi: 10.3969/j.issn.1006-0111.2018.03.012
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