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Volume 36 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(3): 204-209,214

LI Xiuzheng, ZHAO Qingjie, DONG Jiaxiao, JIANG Yunyun, YE Guangming. Research progress in sinomenine structural modification[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 204-209,214. doi: 10.3969/j.issn.1006-0111.2018.03.003
Citation: LI Xiuzheng, ZHAO Qingjie, DONG Jiaxiao, JIANG Yunyun, YE Guangming. Research progress in sinomenine structural modification[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 204-209,214. doi: 10.3969/j.issn.1006-0111.2018.03.003
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Research progress in sinomenine structural modification

doi: 10.3969/j.issn.1006-0111.2018.03.003
  • 1.

    PLA 98 th Clinical College of Anhui Medical University, Huzhou 230032, China

  • 2.

    Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 3.

    No. 101 Hospital of PLA, Wuxi 214044, China

  • Received Date: 2017-10-09
  • Rev Recd Date: 2017-12-29
  • Sinomenine is an alkaloid found in the climbing plant Sinomenium acutum.Structurally, it belongs to the isoquinoline derivatives, which have various bioactivities.Clinically, it is used in the treatment for rheumatism, rheumatoid arthritis and arrhythmia, etc.Nevertheless, due to the need of large dose, photo and thermal instability, quick metabolism in vivo and highly allergic for some patients, scientists have committed to modify its structure to develop the highly effective and low toxic derivatives.In this paper, the recent advances in structural modification of sinomenine are reviewed.
  • [1] 高晨鑫,张湛明,陈继红,等.青藤碱对类风湿关节炎细胞因子影响的研究进展[J].风湿病与关节炎,2017,6(2):72-75.
    [2] Zhao XX,Peng C,Zhang H,et al.Sinomenium acutum:A review of chemistry, pharmacology,pharmacokinetics, and clinical use[J].Pharm Biol,2012, 50(8):1053-1061.
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    [4] 游素芬,戈萌.青藤碱新用途:1679574[P].2005-10-12.
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    [7] 林红卫, 李勇, 朱士龙,等.4-乙酰氧基-5-乙酰基-青藤碱的合成与表征[J].怀化学院学报, 2013, 32(11):31-33.
    [8] 林红卫, 李勇, 朱士龙,等.取代苯偶氮基-青藤碱衍生物的合成与表征[J].化学研究与应用, 2013, 25(11):1575-1579.
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    [14] 罗烈.青藤碱衍生物的合成及镇痛抗炎作用的定量构效关系研究[D].武汉:武汉大学, 2005.
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Research progress in sinomenine structural modification

doi: 10.3969/j.issn.1006-0111.2018.03.003
  • 1. PLA 98 th Clinical College of Anhui Medical University, Huzhou 230032, China
  • 2. Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 3. No. 101 Hospital of PLA, Wuxi 214044, China
  • Received Date: 2017-10-09
  • Rev Recd Date: 2017-12-29

Abstract: Sinomenine is an alkaloid found in the climbing plant Sinomenium acutum.Structurally, it belongs to the isoquinoline derivatives, which have various bioactivities.Clinically, it is used in the treatment for rheumatism, rheumatoid arthritis and arrhythmia, etc.Nevertheless, due to the need of large dose, photo and thermal instability, quick metabolism in vivo and highly allergic for some patients, scientists have committed to modify its structure to develop the highly effective and low toxic derivatives.In this paper, the recent advances in structural modification of sinomenine are reviewed.

LI Xiuzheng, ZHAO Qingjie, DONG Jiaxiao, JIANG Yunyun, YE Guangming. Research progress in sinomenine structural modification[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 204-209,214. doi: 10.3969/j.issn.1006-0111.2018.03.003
Citation: LI Xiuzheng, ZHAO Qingjie, DONG Jiaxiao, JIANG Yunyun, YE Guangming. Research progress in sinomenine structural modification[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 204-209,214. doi: 10.3969/j.issn.1006-0111.2018.03.003
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