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Volume 36 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(2): 131-135

TANG Huanjun. Effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein in patients with hypertensive nephropathy[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 131-135. doi: 10.3969/j.issn.1006-0111.2018.02.008
Citation: TANG Huanjun. Effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein in patients with hypertensive nephropathy[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 131-135. doi: 10.3969/j.issn.1006-0111.2018.02.008
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Effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein in patients with hypertensive nephropathy

doi: 10.3969/j.issn.1006-0111.2018.02.008

  • Sichuan Mianyang 404 Hospital, Mianyang 621000, China

  • Received Date: 2017-11-05
  • Rev Recd Date: 2017-12-25
  • Objective To investigate the effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein regulation. Methods Patients were randomly divided into two groups. The control group received benazepine hydrochloride only. The experimental group received benazepine and spironolactone treatment. The blood pressure, renal function, 24 h urinary protein, Cys-C, GFR, urinary microprotein and the correlation of GFR with Cys-C and urinary microprotein were recorded. Results There was no statistically significant difference between two groups in blood pressure (P>0.05). After treatment, the renal function of the experimental group was significantly improved compared to that of the control group. The 24 h urine protein, Cys-C and urinary microprotein were significantly lower in the experimental group than the control group (P<0.05). GFR was negatively correlated with Cys-C and urinary microprotein. Conclusion The combination therapy of ACEI and aldosterone receptor antagonist can improve renal function and reduce 24 h hematuria. GFR filtration ability was significantly improved with the reduction of Cys-C and urinary microprotein.
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    [2] Blacher J, Levy BI, Mourad JJ, et al. From epidemiological transition to modern cardiovascular epidemiology:hypertension in the 21st century[J]. Lancet, 2016, 388(10043):530-532.
    [3] 中国高血压防治指南修订委员会. 中国高血压防治指南2010[J]. 中华心血管病杂志, 2011, 39(7):579-616.
    [4] 胡昭. 慢性肾脏病高血压及抗高血压药物临床实践指南[C].中华医学会肾脏病学分会2006年学术年会专题讲座,2006:148-155.
    [5] Hallan SI,Ritz E,Lydersen S, et al. Combining GFR and albuminuria to classify CKD improves prediction of ESRD[J]. J Am Soc Nephrol, 2009, 20(5):1069-1077.
    [6] 全中, 郭志勇. 高血压肾病的研究现状[J]. 中国医药导报, 2012, 9(33):32-33.
    [7] James PA, Oparil S, Carter BL, et al. 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults:Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)[J]. Jama, 2014, 311(5):507-520.
    [8] De Nicola L, Provenzano M, Chiodini P, et al. Independent Role of Underlying Kidney Disease on Renal Prognosis of Patients with Chronic Kidney Disease under Nephrology Care[J]. PloS ONE, 2015, 10(5):e0127071.
    [9] Shen JI, Saxena AB, Vangala S, et al. Renin-angiotensin system blockers and residual kidney function loss in patients initiating peritoneal dialysis:an observational cohort study[J]. BMC Nephrol, 2017, 18(1):196.
    [10] Ma TK, Kam K, Yan BP, et al. Renin-angiotensin-aldosterone system blockade for cardiovascular diseases:current status[J]. Br J Pharmacol, 2010, 160(6):1273-1292.
    [11] Kobayashi M, Hirooka K, Ono A, et al. The Relationship Between the Renin-Angiotensin-Aldosterone System and NMDA Receptor-Mediated Signal and the Prevention of Retinal Ganglion Cell Death[J]. Invest Ophthalmol Vis Sci, 2017, 58(3):1397-1403.
    [12] Liu L, Xu B, Ju Y. Addition of spironolactone in patients with resistant hypertension:A meta-analysis of randomized controlled trials[J]. Clin Exp Hypertens, 2017, 39(3):257-263.
    [13] Ching KC, Cohen DL, Fraker DL, et al. Adrenal vein sampling for primary aldosteronism:a 2-week protocol for withdrawal of renin-stimulating antihypertensives[J]. Cardiovascular & Interventional Radiology, 2016, 27(3):1-5.
    [14] Kim JS, Kim MK, Lee JY, et al. The effects of proteinuria on urinary cystatin-C and glomerular filtration rate calculated by serum cystatin-C[J]. Ren Fail, 2012, 34(6):676-684.
    [15] 陈冬莲, 郑身宏, 刘首明,等. Cys-C、HbA1c、GA和U-mAlb/Cr检测对2型糖尿病早期肾损伤的诊断价值[J]. 国际检验医学杂志, 2014,35(6):677-679.
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    [17] Svenningsen P, Andersen H, Nielsen LH, et al. Urinary serine proteases and activation of ENaC in kidney-implications for physiological renal salt handling and hypertensive disorders with albuminuria[J]. Pflügers Archiv:Eur J Physiol, 2015, 467(3):531-542.
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Effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein in patients with hypertensive nephropathy

doi: 10.3969/j.issn.1006-0111.2018.02.008
  • Sichuan Mianyang 404 Hospital, Mianyang 621000, China
  • Received Date: 2017-11-05
  • Rev Recd Date: 2017-12-25

Abstract: Objective To investigate the effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein regulation. Methods Patients were randomly divided into two groups. The control group received benazepine hydrochloride only. The experimental group received benazepine and spironolactone treatment. The blood pressure, renal function, 24 h urinary protein, Cys-C, GFR, urinary microprotein and the correlation of GFR with Cys-C and urinary microprotein were recorded. Results There was no statistically significant difference between two groups in blood pressure (P>0.05). After treatment, the renal function of the experimental group was significantly improved compared to that of the control group. The 24 h urine protein, Cys-C and urinary microprotein were significantly lower in the experimental group than the control group (P<0.05). GFR was negatively correlated with Cys-C and urinary microprotein. Conclusion The combination therapy of ACEI and aldosterone receptor antagonist can improve renal function and reduce 24 h hematuria. GFR filtration ability was significantly improved with the reduction of Cys-C and urinary microprotein.

TANG Huanjun. Effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein in patients with hypertensive nephropathy[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 131-135. doi: 10.3969/j.issn.1006-0111.2018.02.008
Citation: TANG Huanjun. Effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein in patients with hypertensive nephropathy[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 131-135. doi: 10.3969/j.issn.1006-0111.2018.02.008
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