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Volume 36 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(1): 9-12

YUAN Yingchao, LIAO Qiuju. Recent advances of inflammatory cytokines in the diagnosis and treatment of knee osteoarthritis[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 9-12. doi: 10.3969/j.issn.1006-0111.2018.01.002
Citation: YUAN Yingchao, LIAO Qiuju. Recent advances of inflammatory cytokines in the diagnosis and treatment of knee osteoarthritis[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 9-12. doi: 10.3969/j.issn.1006-0111.2018.01.002
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Recent advances of inflammatory cytokines in the diagnosis and treatment of knee osteoarthritis

doi: 10.3969/j.issn.1006-0111.2018.01.002

  • Xuanwu Hospital of Capital Medical University, Beijing 100054, China

  • Received Date: 2017-08-04
  • Rev Recd Date: 2017-09-11
  • Knee osteoarthritis (KOA) is a common chronic degenerative disease in the elderly population. It is characterized by knee-joint pain, swelling, morning stiffness and seriously affects the patients' motor function and physical health. So far, there is no early diagnosis and effective treatment for it. This paper outlined the recent researches on knee osteoarthritis and inflammatory cytokines to discuss the relationship between knee osteoarthritis and inflammatory factors such as IL-1β, IL-6, TNF-α, TGF-β, IL-10,IL-17 and IL-37, and provide the theoretical basis for the diagnosis and treatment of knee osteoarthritis.
  • [1] Dulay GS, Cooper C, Dennison EM. Knee pain, knee injury, knee osteoarthritis & work[J]. Best Pract Res Clin Rheumatol, 2015,29(3):454-461.
    [2] Tang X, Wang S, Zhan S, et al. The Prevalence of Symptomatic Knee Osteoarthritis in China:Results From the China Health and Retirement Longitudinal Study[J]. Arthritis Rheumatol, 2016,68(3):648-653.
    [3] Akdis M, Burgler S, Crameri R, et al. Interleukins, from 1 to 37, and interferon-gamma:receptors, functions, and roles in diseases[J]. J Allergy Clin Immunol, 2011,127(3):701-721.
    [4] Santangelo KS, Nuovo GJ, Bertone AL.In vivo reduction or blockade of interleukin-1beta in primary osteoarthritis influences expression of mediators implicated in pathogenesis[J]. Osteoarthr Cartil,2012, 20(12):1610-1618.
    [5] 何薇, 赵峰, 张国平, 等. 透明质酸对骨关节炎软骨细胞白细胞介素-1β及肿瘤坏死因子-α表达的影响[J].中国老年学杂志, 2017,37(1):25-27.
    [6] 杨黎黎,王庆欢,王欢,等.通络止痛方对人膝骨关节炎关节液IL-1β,HA及NO的影响[J].中国中医骨伤科杂志, 2017,18(3):1-4.
    [7] Cai H, Sun HJ, Wang YH, et al. Relationships of common polymorphisms in IL-6, IL-1A, and IL-1B genes with susceptibility to osteoarthritis:a meta-analysis[J]. Clin Rheumatol, 2015,34(8):1443-1453.
    [8] 金粉勤, 薛锋.膝骨关节炎患者血清TNF-a与IL-6水平检测分析[J].中国实验诊断学, 2014,18(3):461-462.
    [9] Larsson S, Englund M, Struglics A,et al.Interleukin-6 and tumor necrosis factor alpha in synovial fluid are associated with progression of radiographic knee osteoarthritis in subjects with previous meniscectomy[J]. Osteoarthr Cartil, 2015, 23(11):1906-1914.
    [10] Alves AC, Vieira R, Leal-Junior E, et al. Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation[J]. Arthritis Res Ther, 2013,15(5):R116.
    [11] Chen L, Li QD, Zhong J,et al.IL-17RA aptamer-mediated repression of IL-6 inhibits synovium inflammation in a murine model of osteoarthritis[J]. Osteoarthr Cartil,2011,19(6):711-718.
    [12] 杨颖.聚焦超声波对膝关节炎性液中IL-1β、TNF-α及PGE-2的影响[J].海南医学院学报,2013,19(1):123-127.
    [13] Lu W, Wang L,Wo CX,et al.Ketamine attenuates osteoarthritis of the knee via modulation of inflammatory responses in a rabbit model[J]. Mol Med Rep,2016,13(6):5013-5020.
    [14] Waly N E, Refaiy A, Aborehab N M. IL-10 and TGF-β:Roles in chondroprotective effects of Glucosamine in experimental osteoarthritis[J]. Pathophysiology, 2017,24(1):45-49.
    [15] Cherian JJ, Parvizi J, Bramlet D, et al. Preliminary results of a phase Ⅱ randomized study to determine the efficacy and safety of genetically engineered allogeneic human chondrocytes expressing TGF-β1 in patients with grade 3 chronic degenerative joint disease of the knee[J]. Osteoarthr Cartil, 2015,23(12):2109-2118.
    [16] Wen ZH, Tang CC, Chang YC, et al. Calcitonin attenuates cartilage degeneration and nociception in an experimental rat model of osteoarthritis:role of TGF-β in chondrocytes[J]. Sci Rep, 2016,6:28862.
    [17] Hong Y, Kim H, Lee Y, et al. Salutary effects of melatonin combined with treadmill exercise on cartilage damage[J]. J Pineal Res, 2014,57(1):53-66.
    [18] Li S, Wan J, Anderson W, et al. Down regulation of IL-10 secretion by Treg cells in osteoarthritis is associated with a reduction in Tim-3 expression[J]. BiomedPharmacother, 2016,79:159-165.
    [19] Samut G, Dincer F, Ozdemir O.The effect of isokinetic and aerobic exercises on serum interleukin-6 and tumor necrosis factor alpha levels, pain, and functional activity in patients with knee osteoarthritis[J]. Mod Rheumatol, 2015, 25(6):919-924.
    [20] van Geffen EW, van Caam AP, van Beuningen HM,et al.IL-37 dampens the IL1β-induced catabolic status of human OA chondrocytes[J].Rheumatology (Oxford), 2017,56(3):351-361.
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Recent advances of inflammatory cytokines in the diagnosis and treatment of knee osteoarthritis

doi: 10.3969/j.issn.1006-0111.2018.01.002
  • Xuanwu Hospital of Capital Medical University, Beijing 100054, China
  • Received Date: 2017-08-04
  • Rev Recd Date: 2017-09-11

Abstract: Knee osteoarthritis (KOA) is a common chronic degenerative disease in the elderly population. It is characterized by knee-joint pain, swelling, morning stiffness and seriously affects the patients' motor function and physical health. So far, there is no early diagnosis and effective treatment for it. This paper outlined the recent researches on knee osteoarthritis and inflammatory cytokines to discuss the relationship between knee osteoarthritis and inflammatory factors such as IL-1β, IL-6, TNF-α, TGF-β, IL-10,IL-17 and IL-37, and provide the theoretical basis for the diagnosis and treatment of knee osteoarthritis.

YUAN Yingchao, LIAO Qiuju. Recent advances of inflammatory cytokines in the diagnosis and treatment of knee osteoarthritis[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 9-12. doi: 10.3969/j.issn.1006-0111.2018.01.002
Citation: YUAN Yingchao, LIAO Qiuju. Recent advances of inflammatory cytokines in the diagnosis and treatment of knee osteoarthritis[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 9-12. doi: 10.3969/j.issn.1006-0111.2018.01.002
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