Practice of pharmacy consultation on dosage regimen for pediatric epilepsy patient with PPK model

LI Yanping; SUN Zhouliang; LIN Weiwei

doi:10.3969/j.issn.1006-0111.2017.06.019

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Objective In order to provide a reference for optimizing the dosage regimen of carbamazepine and valproate in pediatric epilepsy patients. Methods Pharmacist consulted one pediatric epilepsy patient with traumatic brain injury for post operation epilepsy treatments. The abnormal plasma concentration of carbamazepine and valproic acid was analyzed with the population pharmacokinetic (PPK) model built by this team. New medication regimen was proposed and the predictive capability of this model was evaluated. Results Seizures in this patient have been effectively controlled. Conclusion Pharmacist can optimize the antiepileptic drug treatment with PPK model and achieve rational drug use clinically.

Practice of pharmacy consultation on dosage regimen for pediatric epilepsy patient with PPK model

1. Department of Pharmacy, First Hospital Affiliated to Xiamen University, Xiamen 361000, China;Department of Pharmacy, First Hospital Affiliated to Fujian Medical University, Fuzhou 350004, China

2. Department of Pharmacy, First Hospital Affiliated to Xiamen University, Xiamen 361000, China

3. Department of Pharmacy, First Hospital Affiliated to Fujian Medical University, Fuzhou 350004, China

Received Date: 2016-12-19

Rev Recd Date: 2017-08-03

Key words:

Abstract: Objective In order to provide a reference for optimizing the dosage regimen of carbamazepine and valproate in pediatric epilepsy patients. Methods Pharmacist consulted one pediatric epilepsy patient with traumatic brain injury for post operation epilepsy treatments. The abnormal plasma concentration of carbamazepine and valproic acid was analyzed with the population pharmacokinetic (PPK) model built by this team. New medication regimen was proposed and the predictive capability of this model was evaluated. Results Seizures in this patient have been effectively controlled. Conclusion Pharmacist can optimize the antiepileptic drug treatment with PPK model and achieve rational drug use clinically.

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Practice of pharmacy consultation on dosage regimen for pediatric epilepsy patient with PPK model

doi: 10.3969/j.issn.1006-0111.2017.06.019

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通讯作者: 陈斌, [email protected]

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