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Volume 35 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2017  >  35(6): 551-553,576

WANG Yali, PENG Xiandong, HAO Weiyi, WANG Dan, GUO Tingdong, TANG Zhili. Simultaneous determination of dexamethasone acetate, camphor and phenol in compound cream by HPLC method[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 551-553,576. doi: 10.3969/j.issn.1006-0111.2017.06.017
Citation: WANG Yali, PENG Xiandong, HAO Weiyi, WANG Dan, GUO Tingdong, TANG Zhili. Simultaneous determination of dexamethasone acetate, camphor and phenol in compound cream by HPLC method[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 551-553,576. doi: 10.3969/j.issn.1006-0111.2017.06.017
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Simultaneous determination of dexamethasone acetate, camphor and phenol in compound cream by HPLC method

doi: 10.3969/j.issn.1006-0111.2017.06.017

  • Department of Pharmacy, Nanchong Municipal Central Hospital, Nanchong, 637000, China

  • Received Date: 2017-05-15
  • Rev Recd Date: 2017-07-31
  • Objective To establish a HPLC method for simultaneously determining the content of dexamethasone acetate, camphor and phenol in compound cream. Methods The separation was performed on a SHIADZU-GL Inertsil® ODS-3 RP C18 analytical column with the mobile phase consisting of methanol-water (60:40). The flow rate was 1.0 ml/min. The detection wave length was 285 nm and the column temperature was 40℃. Results Dexamethasone acetate,camphor and phenol showed good linearity (r>0.999 5, n=7) within the concentration range of 4.024-40.24,101.7-2 033 and 10.38-425.2 μg/ml,respectively. The average recovery of dexamethasone acetate, camphor and phenol was 101.2%(RSD was 0.56%),99.89%(RSD was 0.72%),100.2%(RSD was 0.97%),respectively. Moreover, the RSDs were less than 1.5% in the repeated tests. Conclusion The method was simple, quick and accurate. It is suitable for the quality control of dexamethasone acetate camphor and phenol cream.
  • [1] 吴洪文,吴敏.RP-HPLC法测定复方鼻用软膏中醋酸地塞米松含量[J].中国药师,2004,7(7):529-530.
    [2] 李冬,高红英.采用HPLC法测定醋酸地塞米松片的含量[J].中小企业管理与科技,2008(8):174-175.
    [3] 陈江飞,苗彩云.HPLC法测定复方醋酸地塞米松搽剂中醋酸地塞米松和樟脑的含量[J].中国临床药学杂志,2010,19(2):108-111.
    [4] 国家药典委员会. 中华人民共和国药典2015年版二部[S].北京:中国医药科技出版社,2015:1531.
    [5] 张利平,林伟萍,陈健苗,等.高效液相色谱法测定氯霉素地塞米松乳膏中两组分含量[J].中国药业,2008,17(15):26-27.
    [6] 陆松伟,宋洪杰,陈方剑.HPLC法同时测定复方樟脑搽剂中苯酚和樟脑含量[J].药学实践杂志,2011,29(5):347-349.
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Simultaneous determination of dexamethasone acetate, camphor and phenol in compound cream by HPLC method

doi: 10.3969/j.issn.1006-0111.2017.06.017
  • Department of Pharmacy, Nanchong Municipal Central Hospital, Nanchong, 637000, China
  • Received Date: 2017-05-15
  • Rev Recd Date: 2017-07-31

Abstract: Objective To establish a HPLC method for simultaneously determining the content of dexamethasone acetate, camphor and phenol in compound cream. Methods The separation was performed on a SHIADZU-GL Inertsil® ODS-3 RP C18 analytical column with the mobile phase consisting of methanol-water (60:40). The flow rate was 1.0 ml/min. The detection wave length was 285 nm and the column temperature was 40℃. Results Dexamethasone acetate,camphor and phenol showed good linearity (r>0.999 5, n=7) within the concentration range of 4.024-40.24,101.7-2 033 and 10.38-425.2 μg/ml,respectively. The average recovery of dexamethasone acetate, camphor and phenol was 101.2%(RSD was 0.56%),99.89%(RSD was 0.72%),100.2%(RSD was 0.97%),respectively. Moreover, the RSDs were less than 1.5% in the repeated tests. Conclusion The method was simple, quick and accurate. It is suitable for the quality control of dexamethasone acetate camphor and phenol cream.

WANG Yali, PENG Xiandong, HAO Weiyi, WANG Dan, GUO Tingdong, TANG Zhili. Simultaneous determination of dexamethasone acetate, camphor and phenol in compound cream by HPLC method[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 551-553,576. doi: 10.3969/j.issn.1006-0111.2017.06.017
Citation: WANG Yali, PENG Xiandong, HAO Weiyi, WANG Dan, GUO Tingdong, TANG Zhili. Simultaneous determination of dexamethasone acetate, camphor and phenol in compound cream by HPLC method[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 551-553,576. doi: 10.3969/j.issn.1006-0111.2017.06.017
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