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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2017  >  35(6): 485-489

HOU Cheng, LU Guangzhao, LI Wenqing, ZOU Hao. Recent progress in pharmacology, efficacy and dosage forms of flumazenil[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 485-489. doi: 10.3969/j.issn.1006-0111.2017.06.002
Citation: HOU Cheng, LU Guangzhao, LI Wenqing, ZOU Hao. Recent progress in pharmacology, efficacy and dosage forms of flumazenil[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 485-489. doi: 10.3969/j.issn.1006-0111.2017.06.002
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Recent progress in pharmacology, efficacy and dosage forms of flumazenil

doi: 10.3969/j.issn.1006-0111.2017.06.002

  • Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2017-08-18
  • Rev Recd Date: 2017-09-01
  • Flumazenil, a benzodiazepine antagonist, specifically binds the benzodiazepine receptors in central nervous system and reduces the release of gamma-aminobutyric acid. It is used for the reversal of sedative effects of benzodiazepine and benzodiazepine-induced anesthesia. In this article, the clinical applications of flumazenil and the developments of different dosage forms were reviewed.
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    [7] Platt DM, Rowlett JK, Spealman RD, et al. Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABA_A/alpha1-preferring antagonist beta-CCt in squirrel monkeys[J]. Psychopharmacology,2002,164(2):151-159.
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    [10] 张纯洁, 郁娜, 张敏, 等. 纳洛酮、氟马西尼及两药合用对羟丁酸钠麻醉小鼠的催醒作用[J]. 徐州医学院学报,2010,30(2):77-78.
    [11] 刘秀兰, 王芝静. 氟马西尼对丙泊酚的拮抗作用[J]. 中国美容医学,2012,21(8):295-296.
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    [14] Shaaban H, Klukowicz A, Miller R, et al. Continuous intravenous flumazenil infusion in a patient with chlordiazepoxide toxicity and hepatic encephalopathy[J]. J Emerg Traum Shock,2015,8(1):58-60.
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    [17] Vesal N, Zare P. Clinical evaluation of intranasal benzodiazepines, α2-agonists and their antagonists in canaries[J]. Vet Anaesth Analg,2006,33(3):143-148.
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Recent progress in pharmacology, efficacy and dosage forms of flumazenil

doi: 10.3969/j.issn.1006-0111.2017.06.002
  • Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2017-08-18
  • Rev Recd Date: 2017-09-01

Abstract: Flumazenil, a benzodiazepine antagonist, specifically binds the benzodiazepine receptors in central nervous system and reduces the release of gamma-aminobutyric acid. It is used for the reversal of sedative effects of benzodiazepine and benzodiazepine-induced anesthesia. In this article, the clinical applications of flumazenil and the developments of different dosage forms were reviewed.

HOU Cheng, LU Guangzhao, LI Wenqing, ZOU Hao. Recent progress in pharmacology, efficacy and dosage forms of flumazenil[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 485-489. doi: 10.3969/j.issn.1006-0111.2017.06.002
Citation: HOU Cheng, LU Guangzhao, LI Wenqing, ZOU Hao. Recent progress in pharmacology, efficacy and dosage forms of flumazenil[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 485-489. doi: 10.3969/j.issn.1006-0111.2017.06.002
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