QIAN Yujun, QIN Chunxia, SUN Lili, DING Huamin, LI Yiming, LI Tiejun. Clinical efficacy of Scrophularia ningpoensis granules combined with fosinopril for congestive heart failure[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(3): 267-269. doi: 10.3969/j.issn.1006-0111.2017.03.018
| Citation:
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QIAN Yujun, QIN Chunxia, SUN Lili, DING Huamin, LI Yiming, LI Tiejun. Clinical efficacy of Scrophularia ningpoensis granules combined with fosinopril for congestive heart failure[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(3): 267-269. doi: 10.3969/j.issn.1006-0111.2017.03.018
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Clinical efficacy of Scrophularia ningpoensis granules combined with fosinopril for congestive heart failure
- 1.
Department of Pharmacy, Shanghai Punan Hospital of Pudong New District, Shanghai 200125, China
- 2.
Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China
- Received Date: 2017-01-01
- Rev Recd Date:
2017-04-05
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Abstract
Objective To evaluate the efficacy of Scrophularia ningpoensis granules combined with fosinopril in treatment of congestive heart failure. Methods 60 congestive heart failure patients were randomly divided into 2 groups, 30 patients in the treatment group and 30 patients in the control group. Besides the conventional therapy, the control group was treated with fosinopril and the treatment group received Scrophularia ningpoensis granules plus fosinopril for 90 days. Left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular ejection fraction (LVEF) and serum B-type brain natriuretic peptide (BNP) were measured before and after treatment. Results The total effective rate in the treatment group and the control group were 90%, but significantly effective number in the treatment group was higher than the control group. The levels of BNP, LVEDD and LVESD in both groups were decreased, while LVEF was increased after the treatment. The difference was statistically significant (P<0.01). The degree of improvement of heart function in the treatment group was better than that in the control group (P<0.05). Conclusion The combination therapy of Scrophularia ningpoensis granules and fosinopril is efficacious in treating CHF.
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