Evaluation on the clinical utilization of human serum albumin in ICU patients

ZHOU Ting; YANG Zhen; LU Saihua; LIU Xiufeng; ZHANG Ye; XU Feng

doi:10.3969/j.issn.1006-0111.2017.02.018

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

Objective To evaluate the utilization of human serum albumin (HSA) in intensive care unit (ICU) to promote rational use of HSA clinically. Methods Data were collected from the patients received HSA therapy during the period of January 1, 2015 to December 31, 2015. The indications and usage of HSA were analyzed statistically. Results 416 bottles of HSA were administered to 64 patients. The average dose was 62.5g per patient. The most popular indication was for hypoproteinemia (39.1%) followed by encephaledema, craniocerebral trauma, shock and tumors. Before the HSA therapy, 36 patients (56.3%) had albumin level of 15-25 g/L and 23 patients (35.9%) of 25-35 g/L. Conclusion HSA is widely used in ICU for different indications. Some misuses still exist. Guidelines for proper use of HSA are needed to guarantee its rational use. HSA should be used strictly following these guidelines.

Evaluation on the clinical utilization of human serum albumin in ICU patients

1. Department of Pharmacy, South Campus, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 201499, China

2. Department of Pharmacy, Fengxian Hospital, Jinzhou Medical University, Shanghai 201499, China

Received Date: 2016-05-13

Rev Recd Date: 2016-06-16

Key words:

Abstract: Objective To evaluate the utilization of human serum albumin (HSA) in intensive care unit (ICU) to promote rational use of HSA clinically. Methods Data were collected from the patients received HSA therapy during the period of January 1, 2015 to December 31, 2015. The indications and usage of HSA were analyzed statistically. Results 416 bottles of HSA were administered to 64 patients. The average dose was 62.5g per patient. The most popular indication was for hypoproteinemia (39.1%) followed by encephaledema, craniocerebral trauma, shock and tumors. Before the HSA therapy, 36 patients (56.3%) had albumin level of 15-25 g/L and 23 patients (35.9%) of 25-35 g/L. Conclusion HSA is widely used in ICU for different indications. Some misuses still exist. Guidelines for proper use of HSA are needed to guarantee its rational use. HSA should be used strictly following these guidelines.

HTML

Reference (20)

[1]	Fanali G, di Masi A, Trezza V,et al. Human serum albumin:from bench to bedside[J]. Mol Aspects Med,2012,33(3):209-290.
[2]	Mendez CM, McClain CJ, Marsano LS. Albumin therapy in clinical practice[J]. Nutr Clin Pract,2005,20(3):314-320.
[3]	Liberati A, Moja L, Moschetti I, et al. Human albumin solution for resuscitation and volume expansion in critically ill patients[J]. Intern Emerg Med,2006,1(3):243-245.
[4]	Vincent JL. Resuscitation using albumin in critically ill patients:research in patients at high risk of complications is now needed[J]. BMJ,2006,333(7577):1029-1030.
[5]	Zhou T, Lu SH, Liu XF, et al., Review of the rational use and adverse reactions to human serum albumin in the People's Republic of China[J].Patient Prefer Adherence,2013,7:1207-1212.
[6]	Vincent JL, Wilkes MM, Navickis RJ. Safety of human albumin-serious adverse events reported worldwide in 1998-2000[J]. Br J Anaesth,2003,91(5):625-630.
[7]	Sikuler E, Shapira A, Mor-Yosef S, et al. Rational use of albumin[J]. Harefuah, 2000, 139(5-6):190-193, 246.
[8]	Vermeulen LC Jr, Ratko TA, Erstad BL, et al. A paradigm for consensus. The University Hospital Consortium guidelines for the use of albumin, nonprotein colloid, and crystalloid solutions[J]. Arch Intern Med,1995,155(4):373-379.
[9]	Suarez JI, Martin RH, Calvillo E, et al. The albumin in subarachnoid hemorrhage (ALISAH)multicenter pilot clinical trial:safety and neurologic outcomes[J]. Stroke,2012,43(3):683-690.
[10]	赵龙姝,雷鸣,时扣荣,等. 不同浓度人血白蛋白对老年脑出血危重患者的疗效研究[J]. 临床急诊杂志, 2015,16(5):373-375.
[11]	Perel P, Roberts I. Colloids versus crystalloids for fluid resuscitation in critically ill patients[J]. Cochrane Database Syst Rev,2011(3):CD000567.
[12]	Caironi P, Langer T, Gattinoni L.Albumin in critically ill patients:the ideal colloid[J]. Curr Opin Crit Care,2015,21(4):302-308.
[13]	Takahashi I, Ohnuma T, Kavy S, et al. Interaction of human serum albumin with anticancer agents in vitro[J]. Br J Cancer,1980,41(4):602-608.
[14]	Gou Y,Yang F,Liang H. Designing prodrugs based on special residues of human serum albumin[J]. Curr Top Med Chem,2016,16(9):996-1008.
[15]	王丹,陈慧,刘丽宏,等. 172例人血清蛋白临床应用合理性调查与分析[J]. 药学实践杂志,2014,32(3):231-234.
[16]	Ting YX, Wang B. Investigation and analysis of human serum albumin clinical utilization[J]. Chin pharm J,2010,45(13):1035-1038.
[17]	Roberts I, Blackhall K, Alderson P, et al. Human albumin solution for resuscitation and volume expansion in critically ill patients[J]. Cochrane Database Syst Rev, 2011, (11):CD001208.
[18]	Saw MM, Chandler B, Ho KM. Benefits and risks of using gelatin solution as a plasma expander for perioperative and critically ill patients:a meta-analysis[J]. Anaesth Intensive Care,2012,40(1):17-32.
[19]	Pulimood TB,Park GR. Debate:Albumin administration should be avoided in the critically ill[J]. Crit Care,2000,4(3):151-155.
[20]	Finfer S,Bellomo R, Boyce N, et a1.A comparison of albumin and saline for fluid resuscitation in the intensive care unit[J]. N Engl J Med,2004,350(22):2247-2256.

Message Board

Evaluation on the clinical utilization of human serum albumin in ICU patients

doi: 10.3969/j.issn.1006-0111.2017.02.018

Abstract

References

Proportional views

通讯作者: 陈斌, [email protected]

Article Metrics

Related

Proportional views