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Volume 35 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2017  >  35(2): 108-111,140

WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
Citation: WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
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Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states

doi: 10.3969/j.issn.1006-0111.2017.02.003

  • Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2016-12-05
  • Rev Recd Date: 2016-12-27
  • In recent years, pharmacokinetics of traditional Chinese medicine has become essential for the modernization of traditional Chinese medicine. Pharmacokinetics is an important means for connecting traditional Chinese medicine with western medicine. Medications exert efficacy only when there is sufficient concentration at the target sites. The drug concentration is not only related to the dosage, but is also closely correlated to the metabolic processes in human body. Most pharmacokinetic studies of traditional Chinese medicine are based on healthy animals, which ignore significant changes of pharmacokinetic parameters in the diseased state. In this paper, the comparative pharmacokinetics of the traditional Chinese medicine based on animal models in their diseased states was reviewed. Developmental trends of pharmacokinetics of traditional Chinese medicine with different animal models were also discussed.
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Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states

doi: 10.3969/j.issn.1006-0111.2017.02.003
  • Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2016-12-05
  • Rev Recd Date: 2016-12-27

Abstract: In recent years, pharmacokinetics of traditional Chinese medicine has become essential for the modernization of traditional Chinese medicine. Pharmacokinetics is an important means for connecting traditional Chinese medicine with western medicine. Medications exert efficacy only when there is sufficient concentration at the target sites. The drug concentration is not only related to the dosage, but is also closely correlated to the metabolic processes in human body. Most pharmacokinetic studies of traditional Chinese medicine are based on healthy animals, which ignore significant changes of pharmacokinetic parameters in the diseased state. In this paper, the comparative pharmacokinetics of the traditional Chinese medicine based on animal models in their diseased states was reviewed. Developmental trends of pharmacokinetics of traditional Chinese medicine with different animal models were also discussed.

WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
Citation: WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
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