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Volume 35 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2017  >  35(1): 82-86

JIN Haichao, XING Fangkai, CHEN Tao, LV Wenling. Amrubicin as second-line treatment for small-cell lung cancer: a Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 82-86. doi: 10.3969/j.issn.1006-0111.2017.01.021
Citation: JIN Haichao, XING Fangkai, CHEN Tao, LV Wenling. Amrubicin as second-line treatment for small-cell lung cancer: a Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 82-86. doi: 10.3969/j.issn.1006-0111.2017.01.021
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Amrubicin as second-line treatment for small-cell lung cancer: a Meta-analysis

doi: 10.3969/j.issn.1006-0111.2017.01.021
  • 1.

    The 71571 Unit of PLA, Yantai 265500, China

  • 2.

    The Gynecology & Obstetrics of Yuhuangding Hospital, Yantai 265000, China

  • Received Date: 2016-03-07
  • Rev Recd Date: 2016-07-18
  • Objective To evaluate the efficacy and safety of amrubicin for small-cell lung cancer(SCLC). Methods PubMed, Embase, the Cochrane Library and CNKI were searched to collect amrubicin data in the treatment of SCLC. A Meta-analysis was performed over the published clinical trials. The efficacy and safety of amrubicin were evaluated based on overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and toxicity. Results Our analysis for 6 clinical trials indicated that amrubicin had significantly higher ORR than control group[RR 1.72,95% CI (1.39, 2.14),P=0.000], the OS, PFS and toxicity were no-inferior to the control group(P=0.405,P=0.456). Conclusion Amrubicin can be considered as a good second-line treatment for relapsed SCLC.
  • [1] Cheng S, Evans WK, Stys-Norman D, et al. Chemotherapy for relapsed small cell lung cancer:a systematic review and practice guideline[J]. J Thorac Oncol, 2007,2(4):348-354.
    [2] Kim YH, Mishima M. Second-line chemotherapy for small-cell lung cancer (SCLC)[J]. Cancer Treat Rev, 2011,37(2):143-150.
    [3] Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology:a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group[J]. JAMA, 2000,283(15):2008-2012.
    [4] Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J]. Eur J Epidemiol, 2010,25(9):603-605.
    [5] O'Brien ME, Konopa K, Lorigan P, et al. Randomised phase Ⅱ study of amrubicin as single agent or in combination with cisplatin versus cisplatin etoposide as first-line treatment in patients with extensive stage small cell lung cancer-EORTC 08062[J]. Eur J Cancer, 2011,47(15):2322-2330.
    [6] Satouchi M, Kotani Y, Shibata T, et al. Phase Ⅲ study comparing amrubicin plus cisplatin with irinotecan plus cisplatin in the treatment of extensive-disease small-cell lung cancer:JCOG 0509[J]. J Clin Oncol, 2014,32(12):1262-1268.
    [7] Sekine I, Okamoto H, Horai T, et al. A randomized phase Ⅲ study of single-agent amrubicin vs. carboplatin/etoposide in elderly patients with extensive-disease small-cell lung cancer[J]. Clin Lung Cancer, 2014,15(2):96-102.
    [8] Wakuda K, Kenmotsu H, Naito T, et al. Efficacy of rechallenge chemotherapy in patients with sensitive relapsed small cell lung cancer[J]. Am J Clin Oncol, 2015,38(1):28-32.
    [9] Inoue A, Sugawara S, Yamazaki K, et al. Randomized phase Ⅱ trial comparing amrubicin with topotecan in patients with previously treated small-cell lung cancer:North Japan Lung Cancer Study Group Trial 0402[J]. J Clin Oncol, 2008,26(33):5401-5406.
    [10] Inoue A, Sugawara S, Maemondo M, et al. Randomized phase Ⅱ trial comparing amrubicin with re-challenge of platinum doublet in patients with sensitive-relapsed small-cell lung cancer:North Japan Lung Cancer Study Group trial 0702[J]. Lung Cancer, 2015, 89(1):61-65.
    [11] Jotte R, Conkling P, Reynolds C, et al. Randomized phase Ⅱ trial of single-agent amrubicin or topotecan as second-line treatment in patients with small-cell lung cancer sensitive to first-line platinum-based chemotherapy[J]. J Clin Oncol, 2011,29(3):287-293.
    [12] von Pawel J, Jotte R, Spigel DR, et al. Randomized phase Ⅲ trial of amrubicin versus topotecan as second-line treatment for patients with small-cell lung cancer[J]. J Clin Oncol, 2014,32(35):4012-4019.
    [13] Tani N, Yabuki M, Komuro S, et al. Characterization of the enzymes involved in the in vitro metabolism of amrubicin hydrochloride[J]. Xenobiotica, 2005,35(12):1121-1133.
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Amrubicin as second-line treatment for small-cell lung cancer: a Meta-analysis

doi: 10.3969/j.issn.1006-0111.2017.01.021
  • 1. The 71571 Unit of PLA, Yantai 265500, China
  • 2. The Gynecology & Obstetrics of Yuhuangding Hospital, Yantai 265000, China
  • Received Date: 2016-03-07
  • Rev Recd Date: 2016-07-18

Abstract: Objective To evaluate the efficacy and safety of amrubicin for small-cell lung cancer(SCLC). Methods PubMed, Embase, the Cochrane Library and CNKI were searched to collect amrubicin data in the treatment of SCLC. A Meta-analysis was performed over the published clinical trials. The efficacy and safety of amrubicin were evaluated based on overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and toxicity. Results Our analysis for 6 clinical trials indicated that amrubicin had significantly higher ORR than control group[RR 1.72,95% CI (1.39, 2.14),P=0.000], the OS, PFS and toxicity were no-inferior to the control group(P=0.405,P=0.456). Conclusion Amrubicin can be considered as a good second-line treatment for relapsed SCLC.

JIN Haichao, XING Fangkai, CHEN Tao, LV Wenling. Amrubicin as second-line treatment for small-cell lung cancer: a Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 82-86. doi: 10.3969/j.issn.1006-0111.2017.01.021
Citation: JIN Haichao, XING Fangkai, CHEN Tao, LV Wenling. Amrubicin as second-line treatment for small-cell lung cancer: a Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 82-86. doi: 10.3969/j.issn.1006-0111.2017.01.021
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