Distribution of common pathogens and resistance analysis in a tertiary hospital

GONG Li; CHEN Wansheng; TAO Xia; HOU Xingyun

doi:10.3969/j.issn.1006-0111.2016.06.020

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Objective To analyse the distribution of main pathogens and drug resistance in a tertiary hospital during 2014, and to provide the reference for the clinical rational use of antimicrobial agents. Methods Conventional methods were used for bacterial culture, VITEK-2 automatic detection system of French BioMerieux company was used for bacteria identification, and bacterial resistance analysis, and WHO NET 5.5 software was used for data analysis. Results Gram negative bacteria accounted for 78.09%; Gram positive bacteria accounted for 21.91%. Klebsiella pneumoniae detection rate was the highest, that is 16.07%, followed by Escherichia Coli (12.75%), Bauman Acinetobacter (12.69%) and Pseudomonas aeruginosa (10.91%). The resistant rate of methicillin resistant Staphylococcus aureus(MRSA)was 42.8% (101), and the resistant rate of methicillin resistant coagulase negative staphylococci (MRCNS) was 75.62% (152). Resistant rates of Staphylococcus aureus, both coagulase negative staphylococcus and enterococcus faecalis to vancomycin and linezolid were zero. Resistant rates of enterococcus faecium to vancomycin and linezolid were 5.5% and zero respectively. Pathogens were detected mainly in emergency department, and the main pathogens were widely distributed. Conclusion Conducting monitoring of bacterial drug resistance and grasping the change trend of drug resistance have important significance to guide clinical rational drug use.

Distribution of common pathogens and resistance analysis in a tertiary hospital

1. Department of Pharmacy, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai 200003, China;Department of Pharmacy, No. 411 Hospital of PLA, Shanghai 200081, China

2. Department of Pharmacy, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai 200003, China

Received Date: 2015-12-10

Rev Recd Date: 2016-05-04

Key words:

Abstract: Objective To analyse the distribution of main pathogens and drug resistance in a tertiary hospital during 2014, and to provide the reference for the clinical rational use of antimicrobial agents. Methods Conventional methods were used for bacterial culture, VITEK-2 automatic detection system of French BioMerieux company was used for bacteria identification, and bacterial resistance analysis, and WHO NET 5.5 software was used for data analysis. Results Gram negative bacteria accounted for 78.09%; Gram positive bacteria accounted for 21.91%. Klebsiella pneumoniae detection rate was the highest, that is 16.07%, followed by Escherichia Coli (12.75%), Bauman Acinetobacter (12.69%) and Pseudomonas aeruginosa (10.91%). The resistant rate of methicillin resistant Staphylococcus aureus(MRSA)was 42.8% (101), and the resistant rate of methicillin resistant coagulase negative staphylococci (MRCNS) was 75.62% (152). Resistant rates of Staphylococcus aureus, both coagulase negative staphylococcus and enterococcus faecalis to vancomycin and linezolid were zero. Resistant rates of enterococcus faecium to vancomycin and linezolid were 5.5% and zero respectively. Pathogens were detected mainly in emergency department, and the main pathogens were widely distributed. Conclusion Conducting monitoring of bacterial drug resistance and grasping the change trend of drug resistance have important significance to guide clinical rational drug use.

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Distribution of common pathogens and resistance analysis in a tertiary hospital

doi: 10.3969/j.issn.1006-0111.2016.06.020

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通讯作者: 陈斌, [email protected]

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