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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(5): 393-395,473

ZHANG Yue, WANG Jing, LI Tiejun. Progress on the anti-tumor activity of seaweed polysaccharides[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 393-395,473. doi: 10.3969/j.issn.1006-0111.2016.05.003
Citation: ZHANG Yue, WANG Jing, LI Tiejun. Progress on the anti-tumor activity of seaweed polysaccharides[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 393-395,473. doi: 10.3969/j.issn.1006-0111.2016.05.003
shu

Progress on the anti-tumor activity of seaweed polysaccharides

doi: 10.3969/j.issn.1006-0111.2016.05.003
  • 1.

    School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China

  • 2.

    School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2015-12-01
  • Rev Recd Date: 2016-06-21
  • Seaweed polysaccharides are not only a direct inhibitory effect on tumor cells, but also an indirect therapeutic effected by enhancing immune function or inhibiting tumor cell metastasis. Seaweed polysaccharides could inhibit the growth of tumor cells due to reducing tumor chemotherapy drug resistance and inhibiting free radical generation, accelerating free radical scavenging. Moreover, seaweed polysaccharides have a synergistic effect with chemotherapy drugs to reduce their side effects and protest patients from radiotherapy-induced immune cell damage. Therefore, seaweed polysaccharide could be used as adjuvant therapeutic agents. the antitumor activity and mechanism of seaweed polysaccharides were summarized, covering 28 articles published in the years from 2004 to 2015.
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    [2] 刘继筑,李光耀.海洋抗肿瘤活性物质的研究进展[J]. 山东医药,2008,48(44):114-115.
    [3] Wang LC,Wang XY,Wu H, et al. Overview on biological activities and molecular characteristics of sulfated polysaccharides from marine green algae in recent years[J].Mar Drugs,2014,12(10):4984-5020.
    [4] 王庭欣,夏立娅,吴广臣,等.海带多糖对小鼠T淋巴细胞及NK细胞活性的影响[J].河北大学学报,2008,6(28):656-658.[5] 薛 磊.海带多糖的药用研究进展[J].安徽农业科学,2015,43(17):388-390.
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    [8] 孙文忠,魏媛媛,曾曼丽,等.海带多糖对人鼻咽癌 HONE1 细胞裸鼠移植瘤的抑制及凋亡相关基因的调控[J].实用医学杂志,2013,29(4):535-537.
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    [11] Zhang W,Oda T,Yu Q, et al.Fucoidan from macrocystis pyrifera has powerful immune-modulatory effects compared to three other fucoidans[J].Mar Drugs,2015,13(2):1084-1104.
    [12] 王庭欣,夏立娅,吴广臣,等.海带多糖对小鼠T淋巴细胞及NK细胞活性的影响[J].河北大学学报,2008,28(6):656-658.
    [13] Aguilar-Briseño JA,Cruz-Suarez LE, Sassi JF,et al.Sulphated polysaccharides from ulva clathrata and cladosiphon okamuranus seaweeds both inhibit viral attachment/entry and cell-cell fusion, in NDV infection[J]. Mar Drugs,2015,13(7):697-712.
    [14] 王琪琳,桑 青,曲爱琴.海带多糖对环磷酰胺所致白细胞减少保护作用的实验研究[J].山东医药,2009,49(11):48-49.
    [15] 王琪琳.海带硫酸多糖对小鼠腹腔巨噬细胞IL-1分泌功能的研究[J].聊城大学学报,2007,20(4):51-53.
    [16] 王琪琳,赵子鹏.海带硫酸多糖对小鼠腹腔巨噬细胞激活及细胞毒作用的影响[J].聊城大学学报,2004,17(2):56-57.
    [17] 梁杰珍,孙文忠,徐志文,等.海带多糖对放疗后颌下腺细胞凋亡的影响[J].重庆医学,2011,40(15):1466-1470.
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Progress on the anti-tumor activity of seaweed polysaccharides

doi: 10.3969/j.issn.1006-0111.2016.05.003
  • 1. School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China
  • 2. School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2015-12-01
  • Rev Recd Date: 2016-06-21

Abstract: Seaweed polysaccharides are not only a direct inhibitory effect on tumor cells, but also an indirect therapeutic effected by enhancing immune function or inhibiting tumor cell metastasis. Seaweed polysaccharides could inhibit the growth of tumor cells due to reducing tumor chemotherapy drug resistance and inhibiting free radical generation, accelerating free radical scavenging. Moreover, seaweed polysaccharides have a synergistic effect with chemotherapy drugs to reduce their side effects and protest patients from radiotherapy-induced immune cell damage. Therefore, seaweed polysaccharide could be used as adjuvant therapeutic agents. the antitumor activity and mechanism of seaweed polysaccharides were summarized, covering 28 articles published in the years from 2004 to 2015.

ZHANG Yue, WANG Jing, LI Tiejun. Progress on the anti-tumor activity of seaweed polysaccharides[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 393-395,473. doi: 10.3969/j.issn.1006-0111.2016.05.003
Citation: ZHANG Yue, WANG Jing, LI Tiejun. Progress on the anti-tumor activity of seaweed polysaccharides[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 393-395,473. doi: 10.3969/j.issn.1006-0111.2016.05.003
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