Study on quality control of Minuo Hair Solution

Yan Linping; Bai Lingling; Huang Jing; Wang Ting; Su Hua; Liao Xin

doi:10.3969/j.issn.1006-0111.2016.04.015

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Objective To improve the quality standard of Minuo Hair Solution and to ensure product quality. Methods Thin layer chromatography (TLC) and UV-visible spectroscopy (UV-Vis) method was used for the qualitative identification of Angelica sinensis, Paeoniae Radix Rubra, Dictamni Cortex and minoxidil respectively. The Quantitive determination of minoxidil was completed by first order derivative spectroscopy. Results The spots in TLC were clear without inference. And the same color spots appeared in the corresponding position of references and reference drugs. The UV-Vis spectral absorption of minoxidil were in (230±3), (262±3),(286±3) nm. The linear range of minoxidil was obtained between 6.2 and 18.6 μg/ml (r=0.9997). The average recovery was 99.4% (RSD=0.22%). Conclusion The method is simple,accurate and reproducible,and can be effectively used to control the quality of Minuo Hair Solution.

Study on quality control of Minuo Hair Solution

Department of Preparation Division, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China

Received Date: 2015-08-23

Rev Recd Date: 2016-02-26

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Abstract: Objective To improve the quality standard of Minuo Hair Solution and to ensure product quality. Methods Thin layer chromatography (TLC) and UV-visible spectroscopy (UV-Vis) method was used for the qualitative identification of Angelica sinensis, Paeoniae Radix Rubra, Dictamni Cortex and minoxidil respectively. The Quantitive determination of minoxidil was completed by first order derivative spectroscopy. Results The spots in TLC were clear without inference. And the same color spots appeared in the corresponding position of references and reference drugs. The UV-Vis spectral absorption of minoxidil were in (230±3), (262±3),(286±3) nm. The linear range of minoxidil was obtained between 6.2 and 18.6 μg/ml (r=0.9997). The average recovery was 99.4% (RSD=0.22%). Conclusion The method is simple,accurate and reproducible,and can be effectively used to control the quality of Minuo Hair Solution.

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Reference (9)

[1]	曹蕾,王磊,杜旭峰,等. 雄激素性秃发治疗研究进展[J]. 临床皮肤科杂志,2015,44(2):129-132.
[2]	叶艳婷,曹慧,李水凤,等. 5%米诺地尔治疗33例女性型脱发治疗前后的临床和皮肤镜观察[J]. 临床皮肤科杂志,2014,43(12):739-741.
[3]	邓伟. 外用米诺地尔治疗女性雄激素性脱发的系统评价[J]. 四川医学,2012,33(2):261-264.
[4]	国家药典委员会.中华人民共和国药典2010年版一部[S].北京:中国医药科技出版社,2010:附录Ⅵ B, 附录ⅤA.
[5]	刘宁.消栓口服液的薄层色谱法鉴别研究[J]. 药物分析杂志,2008,28(11):1937-1939.
[6]	张晓明,何晓英. 冠心康颗粒质量标准研究[J]. 中国药事,2010,24(4):380-382.
[7]	孟德胜,傅若秋,吴畏. 5%米诺地尔搽剂的制备及稳定性[J]. 药学服务与研究,2010,10(3):189-190.
[8]	朱利霞,张汉扬,杨春云,等. 白鲜皮药材的质量标准研究[J]. 中华中医药学刊,2015,33(1):155-159.
[9]	谢苗,蓝海. 天然药物分析方法的研究进展[J]. 安徽农业科学,2014,42(29):10059-10062,10065.

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Study on quality control of Minuo Hair Solution

doi: 10.3969/j.issn.1006-0111.2016.04.015

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通讯作者: 陈斌, [email protected]

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