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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(3): 258-260,266

HU Wenjun, DENG Zhaohui, LI Aihong, CI Wei. Quality of control of compound chlorhexidine acetate ointment[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 258-260,266. doi: 10.3969/j.issn.1006-0111.2016.03.017
Citation: HU Wenjun, DENG Zhaohui, LI Aihong, CI Wei. Quality of control of compound chlorhexidine acetate ointment[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 258-260,266. doi: 10.3969/j.issn.1006-0111.2016.03.017
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Quality of control of compound chlorhexidine acetate ointment

doi: 10.3969/j.issn.1006-0111.2016.03.017
  • 1.

    Institute for Drug and Instrument Control, Guangzhou Military Region, Guangzhou 510500, China

  • 2.

    School of Pharmacy, Southern Medical University, Guangzhou 510500, China

  • Received Date: 2014-10-25
  • Rev Recd Date: 2015-03-18
  • Objective To improve the standard of the quality control of compound chlorhexidine acetate ointment. Methods TLC was used to control the quality of menthol crystal and camphor. A method to determine chlorhexidine acetate and cocaine hydrochloride simultaneously by HPLC was established. Results The spots of menthol crystal and camphor in TLC were clear. Chlorhexidine acetate and cocaine hydrochloride showed excellent linearity, which were at the range of 10.01-160.14 μg/ml and 10.01-160.14 μg/ml, respectively. The average recoveries were 101.5% (RSD=1.8%) and 100.5% (RSD=2.8%). Conclusion The methods were simple, sensitive and with good reproducibility and could be used to control the quality of compound chlorhexidine acetate ointment.
  • [1] 中国人民解放军总后勤部卫生部.中国人民解放军医疗机构制剂规范2002年版[S].北京:人民军医出版社,2002:164.
    [2] 国家药典委员会.中华人民共和国药典2010年版二部[S].北京:中国医药科技出版社,2010:附录29-31.
    [3] 中华人民共和国卫生部. 中华人民共和国卫生部消毒技术规范2008版[S].北京:国家标准出版社,2008:121-122.
    [4] 李小荣. 高效液相色谱法测定醋酸氯己定缓释凝胶中醋酸氯己定的含量[J].中国医院药学杂志,2008,28(19):1726-1727.
    [5] 卢素格, 刘红丽,杨瑞春. 高效液相色谱测定皮肤消毒液中醋酸氯己定含量[J]. 中国消毒学杂志,2011,28(3):317-318.
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Quality of control of compound chlorhexidine acetate ointment

doi: 10.3969/j.issn.1006-0111.2016.03.017
  • 1. Institute for Drug and Instrument Control, Guangzhou Military Region, Guangzhou 510500, China
  • 2. School of Pharmacy, Southern Medical University, Guangzhou 510500, China
  • Received Date: 2014-10-25
  • Rev Recd Date: 2015-03-18

Abstract: Objective To improve the standard of the quality control of compound chlorhexidine acetate ointment. Methods TLC was used to control the quality of menthol crystal and camphor. A method to determine chlorhexidine acetate and cocaine hydrochloride simultaneously by HPLC was established. Results The spots of menthol crystal and camphor in TLC were clear. Chlorhexidine acetate and cocaine hydrochloride showed excellent linearity, which were at the range of 10.01-160.14 μg/ml and 10.01-160.14 μg/ml, respectively. The average recoveries were 101.5% (RSD=1.8%) and 100.5% (RSD=2.8%). Conclusion The methods were simple, sensitive and with good reproducibility and could be used to control the quality of compound chlorhexidine acetate ointment.

HU Wenjun, DENG Zhaohui, LI Aihong, CI Wei. Quality of control of compound chlorhexidine acetate ointment[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 258-260,266. doi: 10.3969/j.issn.1006-0111.2016.03.017
Citation: HU Wenjun, DENG Zhaohui, LI Aihong, CI Wei. Quality of control of compound chlorhexidine acetate ointment[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 258-260,266. doi: 10.3969/j.issn.1006-0111.2016.03.017
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