GU Shenyong, ZHU Qiuzhen, WANG Jing, LIU Yulan, ZHANG Yue, RUI Yaocheng, ZHANG Yuefan, LI Tiejun. Protective effects and mechanism of Asiatic Acid on traumatic brain injury[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 206-209,288. doi: 10.3969/j.issn.1006-0111.2016.03.004
| Citation:
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GU Shenyong, ZHU Qiuzhen, WANG Jing, LIU Yulan, ZHANG Yue, RUI Yaocheng, ZHANG Yuefan, LI Tiejun. Protective effects and mechanism of Asiatic Acid on traumatic brain injury[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 206-209,288. doi: 10.3969/j.issn.1006-0111.2016.03.004
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Protective effects and mechanism of Asiatic Acid on traumatic brain injury
- 1.
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Department of Pharmacy, Zhongshan Hospital Qingpu Branch Affiliated to Fudan University, Shanghai 201700, China
- 2.
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- 3.
School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China
- Received Date: 2016-03-18
- Rev Recd Date:
2016-04-01
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Abstract
Objective To study the protective effects and mechanism of Asiatic Acid (AA) on traumatic brain injury. Methods The closed craniocerebral injury model made by the weight-drop method and fluid percussion brain injury model were used in the study. Brain water content, blood brain barrier permeability and brain tissue pathology morphology were measured to study the neuroprotective effect of AA on traumatic brain injury. Moreover, the inflammatory cytokines such as TNF-α, IL-β, IL-6 were examined by PCR and ELISA to study the mechanism of AA. Results Brain water content and permeability of blood brain barrier were significantly decreased, the traumatic brain injury was nameliorated by AA. Moreover, the expressions of inflammatory cytokines TNF-α, IL-β, IL-6 were inhibited by AA. Conclusion AA has the protective effects on traumatic brain injury and the mechanism is related to the anti-inflammatory effect.
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