Research progress of drug-loading gold nanoparticles

ZHANG Xin; LIU Ying; FENG Nianping

doi:10.3969/j.issn.1006-0111.2016.03.002

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2016 > 34(3): 196-200,236

ZHANG Xin, LIU Ying, FENG Nianping. Research progress of drug-loading gold nanoparticles[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 196-200,236. doi: 10.3969/j.issn.1006-0111.2016.03.002

Citation:

ZHANG Xin, LIU Ying, FENG Nianping. Research progress of drug-loading gold nanoparticles[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 196-200,236. doi: 10.3969/j.issn.1006-0111.2016.03.002

Research progress of drug-loading gold nanoparticles

doi: 10.3969/j.issn.1006-0111.2016.03.002

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Received Date: 2015-10-29
Rev Recd Date: 2016-01-29

Abstract

In recent years, as a novel drug delivery system, gold nanoparticles have attracted widespread attention. Because of their special physicochemical properties, such as quantum size effect, unique optical phenomenon, easily reacting with thiol compounds or disulfides and so on, gold nanoparticles can delivery variety of types of drugs, like proteins, nucleic acid, small molecular drugs, therefore they can be applied in tumor treatment and detection. In this paper the preparation of drug-loading gold nanoparticles, their drug-loading ways and safety issues were reviewed.
- gold nanoparticles,
- preparation methods,
- drug-loading ways,
- safety,
- conjugate

References

[1]	Luan QF, Zhou KB, Tan HN, et al. Au-NPs enhanced SPR biosensor based on hairpin DNA without the effect of nonspecific adsorption[J]. Biosens Bioelectron, 2011, 26(5):2473-2477.
[2]	Lee H, Lee K, Kim IK, et al. Fluorescent gold nanoprobe sensitive to intracellular reactive oxygen species[J].Adv Funct Mater, 2009, 19(12):1884-1890.
[3]	Rana S, Bajaj A, Mout R, et al. Monolayer coated gold nanoparticles for delivery applications[J]. Adv Drug Deliv Rev, 2012, 64(2):200-216.
[4]	Kumar A, Zhang X, Liang XJ. Gold nanoparticles:Emerging paradigm for targered drug delivery system[J]. Biotechnol Adv, 2013, 31(5):593-606.
[5]	Li L, Nurunnabi M, Nafiujjaman M, et al. GSH-mediated photoactivity of pheophorbide a-conjugated haparin/gold nanoparticle for photodynamic therapy[J]. J Control Release, 2013, 171:241-250.
[6]	Rahman WN, Corde S, Yaqi N, et al. Optimal energy for cell radiosensitivity enhancement by gold nanoparticles using synchrotron-based monoenergetic photo beams[J]. Int J Nanomedicine, 2014, 9:2459-2467.
[7]	Van de Broek B, Devoogdt N, D'Hollander A, et al. Specific cell targeting with nanobody conjugated branched gold nanoparticles for photothermal therapy[J]. ACS Nano, 2011, 5(6):4319-4328.
[8]	Ganeshkumar M, Ponrasu T, Raja MT, et al. Green synthesis of pullulan stabilized gold nanoparticles for cancer targeted drug delivery[J]. Spectrochim Acta A Mol Biomol Spectrosc, 2014, 130:64-71.
[9]	Southam G, Beveridge TJ. The occurence of sulfur and phosphorus within bacterially derived crystalline and pseudocrystalline octahedral gold formed in vitro[J]. Geochim Cosmochim Acta, 1996, 60(20):4369-4376.
[10]	Wen L, Lin ZH, Gu PY, et al. Extracellular biosynthesis of monodispersed gold nanoparticles by a SAM capping route[J]. J Nanopart Res, 2009, 11(2):279-288.
[11]	Kumar KP, Paul W, Sharma CP. Green synthesis of gold nanoparticles with Zingiber officinale extract:Characterization and blood compatibility[J]. Process Biochem, 2011, 46(10):2007-2013.
[12]	Guo QQ, Guo QL, Yuan J, et al. Biosynthesis of gold nanoparticles using a kind of flavonol Dihydromyricetin[J]. Colloids Suraces A Physicochem Eng Asp, 2014, 441:127-132.
[13]	Woehrle GH, Brown LO, Hutchison JE. Thiol-functionalized,1.5-nm gold nanoparticles through ligand exchange reactions:scope and mechanism of ligand exchange[J]. J Am Chem Soc, 2005, 127(7):2172-2183.
[14]	Shem PM, Sardar R, Shumaker-parry JS. Soft ligand stabilized gold nanoparticles:Incorporation of bipyridyls and two-dimensional assembly[J]. J Colloid Interface Sci, 2014, 426:107-116.
[15]	Tatarchuk VV, Sergievskaya AP, Zaikovsky VI, et al. Hydrophilic gold nanoparticles stabilized with tris(2-aminoethyl)amine:Preparation and characterization[J]. Colloids Surf A Physicochem Eng Asp, 2014, 441:496-503.
[16]	Hamaguchi K, Kawasaki H, Arakawa R.Photochemical synthesis of glycine-stabilized gold nanoparticles and its heavy-metal-induced aggregation behavior[J]. Colloids Surf A Physicochem Eng Asp, 2010, 367(1-3):167-173.
[17]	Kim ST, Chompoosor A, Yeh YC, et al. Dendronized gold nanoparticles for siRNA delivery[J]. Small, 2012, 8(21):3253-3256.
[18]	Kim CK, Ghosh P, Pagliuca C, et al. Entrapment of hydrophobic drugs in nanoparticle monolayers with efficient release into cancer cells[J]. J Am Chem Soc, 2009, 131(4):1360-1361.
[19]	Ding Y, Zhou YY, Chen H,et al. The performance of thiol-terminated PEG paclitaxel-conjugated gold nanoparticles[J]. Biomaterials, 2013, 34(38):10217-10227.
[20]	Brown SD, Nativo P, Smith JA, et al. Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin[J]. J Am Chem Soc, 2010, 132(13):4678-4684.
[21]	Sánchez-Paradinas S, Pérez-Andrés M, Almendral-Parra MJ, et al. Enhanced cytotoxic activity of bile acid cisplatin derivatives by conjugation with gold nanoparticles[J]. J Inorq Biochem, 2014, 131:8-11.
[22]	Kao HW,Lin YY,Chen CC, et al. Biological characterization of cetuximab-conjugated gold nanoparticles in a tumor animal model[J]. Nanotechnology, 2014, 25(29):295102.
[23]	Joshi P, Chakraborti S, Ramirez-Vick JE, et al. The anticancer activity of chloroquine gold nanoparticles against MCF-7 breast cancer cells[J]. Colloids Surf B Biointerfaces, 2012, 95(15):195-200.
[24]	Vigderman L, Zubarev ER. Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecles[J]. Adv Drug Deliv Rev, 2013, 65(5):663-676.
[25]	Choi CH, Alabi CA, Webster P, et al. Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles[J]. Proc Nati Acad Sci U S A, 2010, 107(3):1235-1240.
[26]	Zhang ZW, Jia J, Lai YQ, et al. Conjugating folic acid to gold nanoparticles through glutathione for targeting and detecting cancer cells[J]. Bioorg Med Chem, 2010, 18(15):5528-5534.
[27]	Marangoni VS, Paino IM, Zucolotto V. Synthesis and characterization of jacalin-gold nanoparticles conjugates as specific markers for cancer cells[J]. Colloids Surf B Biointerfaces, 2013, 112:380-386.
[28]	Eshghi H, Sazgarnia A, Rahimizadeh M, et al. Protoporphyrin Ⅸ-gold nanoparticle conjugates as an efficient photosensitizer in cervical cancer therapy[J]. Photodiagnosis Photodyn Ther, 2013, 10(3):304-312.
[29]	Bao QY, Geng DD, Xue JW, et al. Glutathione-mediated drug release from Tiopronin-conjugated gold nanoparticles for acute liver injury therapy[J]. Int J Pharm, 2013, 446(1-2):112-118.
[30]	Shen GY,Zhang SB, Hu X. Signal enhancement in a lateral flow immunoassay based on dual gold nanoparticle conjugates[J]. Clin Biochem, 2013, 46(16-17):1734-1738.
[31]	Liu L, Du J, Li SJ, et al. Amplified voltammetric detection of dopamine using ferrocene-capped gold nanoparticle/streptavidin conjugates[J]. Biosens Bioelectron, 2013, 41:730-735.
[32]	Figueroa ER, Lin AY, Yan JX, et al. Optimization of PAMAM-gold nanoparticle conjugation for gene therapy[J]. Biomaterials, 2014, 35(5):1725-1734.
[33]	Haller E, Lindner W, Lämmerhofer M. Gold nanoparticle-antibody conjugates for specific extraction and subsequent analysis by liquid chromatography-tandem mass spectrometry of malondialdehyde-modified low density lipoprotein as biomarker for cardiovascular[J]. Anal Chim Acta, 2015, 857:53-63.
[34]	Ramezani F, Habibi M, Rafii-Tabar H, et al. Effect of peptide length on the conjugation to the gold nanoparticle surface:a molecular dynamic study[J]. Daru, 2015, 23(1):9-13.
[35]	Li N, Zhao PX, Astruc D. Anisotropic gold nanoparticles:synthesis, properties, applications, and toxicity[J]. Angew Chem Int Ed Engl, 2014,53(7):1756-1789.
[36]	Connor EE, Mwamuka J, Gole A, et al. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity[J]. Small, 2005, 1(3):325-327.

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通讯作者: 陈斌, [email protected]

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沈阳化工大学材料科学与工程学院沈阳 110142

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Research progress of drug-loading gold nanoparticles

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Received Date: 2015-10-29

Rev Recd Date: 2016-01-29

Key words:

Abstract: In recent years, as a novel drug delivery system, gold nanoparticles have attracted widespread attention. Because of their special physicochemical properties, such as quantum size effect, unique optical phenomenon, easily reacting with thiol compounds or disulfides and so on, gold nanoparticles can delivery variety of types of drugs, like proteins, nucleic acid, small molecular drugs, therefore they can be applied in tumor treatment and detection. In this paper the preparation of drug-loading gold nanoparticles, their drug-loading ways and safety issues were reviewed.

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Reference (36)

[1]	Luan QF, Zhou KB, Tan HN, et al. Au-NPs enhanced SPR biosensor based on hairpin DNA without the effect of nonspecific adsorption[J]. Biosens Bioelectron, 2011, 26(5):2473-2477.
[2]	Lee H, Lee K, Kim IK, et al. Fluorescent gold nanoprobe sensitive to intracellular reactive oxygen species[J].Adv Funct Mater, 2009, 19(12):1884-1890.
[3]	Rana S, Bajaj A, Mout R, et al. Monolayer coated gold nanoparticles for delivery applications[J]. Adv Drug Deliv Rev, 2012, 64(2):200-216.
[4]	Kumar A, Zhang X, Liang XJ. Gold nanoparticles:Emerging paradigm for targered drug delivery system[J]. Biotechnol Adv, 2013, 31(5):593-606.
[5]	Li L, Nurunnabi M, Nafiujjaman M, et al. GSH-mediated photoactivity of pheophorbide a-conjugated haparin/gold nanoparticle for photodynamic therapy[J]. J Control Release, 2013, 171:241-250.
[6]	Rahman WN, Corde S, Yaqi N, et al. Optimal energy for cell radiosensitivity enhancement by gold nanoparticles using synchrotron-based monoenergetic photo beams[J]. Int J Nanomedicine, 2014, 9:2459-2467.
[7]	Van de Broek B, Devoogdt N, D'Hollander A, et al. Specific cell targeting with nanobody conjugated branched gold nanoparticles for photothermal therapy[J]. ACS Nano, 2011, 5(6):4319-4328.
[8]	Ganeshkumar M, Ponrasu T, Raja MT, et al. Green synthesis of pullulan stabilized gold nanoparticles for cancer targeted drug delivery[J]. Spectrochim Acta A Mol Biomol Spectrosc, 2014, 130:64-71.
[9]	Southam G, Beveridge TJ. The occurence of sulfur and phosphorus within bacterially derived crystalline and pseudocrystalline octahedral gold formed in vitro[J]. Geochim Cosmochim Acta, 1996, 60(20):4369-4376.
[10]	Wen L, Lin ZH, Gu PY, et al. Extracellular biosynthesis of monodispersed gold nanoparticles by a SAM capping route[J]. J Nanopart Res, 2009, 11(2):279-288.
[11]	Kumar KP, Paul W, Sharma CP. Green synthesis of gold nanoparticles with Zingiber officinale extract:Characterization and blood compatibility[J]. Process Biochem, 2011, 46(10):2007-2013.
[12]	Guo QQ, Guo QL, Yuan J, et al. Biosynthesis of gold nanoparticles using a kind of flavonol Dihydromyricetin[J]. Colloids Suraces A Physicochem Eng Asp, 2014, 441:127-132.
[13]	Woehrle GH, Brown LO, Hutchison JE. Thiol-functionalized,1.5-nm gold nanoparticles through ligand exchange reactions:scope and mechanism of ligand exchange[J]. J Am Chem Soc, 2005, 127(7):2172-2183.
[14]	Shem PM, Sardar R, Shumaker-parry JS. Soft ligand stabilized gold nanoparticles:Incorporation of bipyridyls and two-dimensional assembly[J]. J Colloid Interface Sci, 2014, 426:107-116.
[15]	Tatarchuk VV, Sergievskaya AP, Zaikovsky VI, et al. Hydrophilic gold nanoparticles stabilized with tris(2-aminoethyl)amine:Preparation and characterization[J]. Colloids Surf A Physicochem Eng Asp, 2014, 441:496-503.
[16]	Hamaguchi K, Kawasaki H, Arakawa R.Photochemical synthesis of glycine-stabilized gold nanoparticles and its heavy-metal-induced aggregation behavior[J]. Colloids Surf A Physicochem Eng Asp, 2010, 367(1-3):167-173.
[17]	Kim ST, Chompoosor A, Yeh YC, et al. Dendronized gold nanoparticles for siRNA delivery[J]. Small, 2012, 8(21):3253-3256.
[18]	Kim CK, Ghosh P, Pagliuca C, et al. Entrapment of hydrophobic drugs in nanoparticle monolayers with efficient release into cancer cells[J]. J Am Chem Soc, 2009, 131(4):1360-1361.
[19]	Ding Y, Zhou YY, Chen H,et al. The performance of thiol-terminated PEG paclitaxel-conjugated gold nanoparticles[J]. Biomaterials, 2013, 34(38):10217-10227.
[20]	Brown SD, Nativo P, Smith JA, et al. Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin[J]. J Am Chem Soc, 2010, 132(13):4678-4684.
[21]	Sánchez-Paradinas S, Pérez-Andrés M, Almendral-Parra MJ, et al. Enhanced cytotoxic activity of bile acid cisplatin derivatives by conjugation with gold nanoparticles[J]. J Inorq Biochem, 2014, 131:8-11.
[22]	Kao HW,Lin YY,Chen CC, et al. Biological characterization of cetuximab-conjugated gold nanoparticles in a tumor animal model[J]. Nanotechnology, 2014, 25(29):295102.
[23]	Joshi P, Chakraborti S, Ramirez-Vick JE, et al. The anticancer activity of chloroquine gold nanoparticles against MCF-7 breast cancer cells[J]. Colloids Surf B Biointerfaces, 2012, 95(15):195-200.
[24]	Vigderman L, Zubarev ER. Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecles[J]. Adv Drug Deliv Rev, 2013, 65(5):663-676.
[25]	Choi CH, Alabi CA, Webster P, et al. Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles[J]. Proc Nati Acad Sci U S A, 2010, 107(3):1235-1240.
[26]	Zhang ZW, Jia J, Lai YQ, et al. Conjugating folic acid to gold nanoparticles through glutathione for targeting and detecting cancer cells[J]. Bioorg Med Chem, 2010, 18(15):5528-5534.
[27]	Marangoni VS, Paino IM, Zucolotto V. Synthesis and characterization of jacalin-gold nanoparticles conjugates as specific markers for cancer cells[J]. Colloids Surf B Biointerfaces, 2013, 112:380-386.
[28]	Eshghi H, Sazgarnia A, Rahimizadeh M, et al. Protoporphyrin Ⅸ-gold nanoparticle conjugates as an efficient photosensitizer in cervical cancer therapy[J]. Photodiagnosis Photodyn Ther, 2013, 10(3):304-312.
[29]	Bao QY, Geng DD, Xue JW, et al. Glutathione-mediated drug release from Tiopronin-conjugated gold nanoparticles for acute liver injury therapy[J]. Int J Pharm, 2013, 446(1-2):112-118.
[30]	Shen GY,Zhang SB, Hu X. Signal enhancement in a lateral flow immunoassay based on dual gold nanoparticle conjugates[J]. Clin Biochem, 2013, 46(16-17):1734-1738.
[31]	Liu L, Du J, Li SJ, et al. Amplified voltammetric detection of dopamine using ferrocene-capped gold nanoparticle/streptavidin conjugates[J]. Biosens Bioelectron, 2013, 41:730-735.
[32]	Figueroa ER, Lin AY, Yan JX, et al. Optimization of PAMAM-gold nanoparticle conjugation for gene therapy[J]. Biomaterials, 2014, 35(5):1725-1734.
[33]	Haller E, Lindner W, Lämmerhofer M. Gold nanoparticle-antibody conjugates for specific extraction and subsequent analysis by liquid chromatography-tandem mass spectrometry of malondialdehyde-modified low density lipoprotein as biomarker for cardiovascular[J]. Anal Chim Acta, 2015, 857:53-63.
[34]	Ramezani F, Habibi M, Rafii-Tabar H, et al. Effect of peptide length on the conjugation to the gold nanoparticle surface:a molecular dynamic study[J]. Daru, 2015, 23(1):9-13.
[35]	Li N, Zhao PX, Astruc D. Anisotropic gold nanoparticles:synthesis, properties, applications, and toxicity[J]. Angew Chem Int Ed Engl, 2014,53(7):1756-1789.
[36]	Connor EE, Mwamuka J, Gole A, et al. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity[J]. Small, 2005, 1(3):325-327.

Message Board

Research progress of drug-loading gold nanoparticles

doi: 10.3969/j.issn.1006-0111.2016.03.002

Abstract

References

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通讯作者: 陈斌, [email protected]

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