Orthogonal design optimization in synthesis of novel triazole antifungal compounds as key intermediates

WU Junqi; YE Xiaofei; HUANG Lei; CHAI Xiaoyun; JIN Yongsheng; YU Shichong

doi:10.3969/j.issn.1006-0111.2016.02.018

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Objective To optimize novel triazole antifungal compounds synthesis of key intermediates. Methods The orthogonal experimental design is used, emphasizing on four factors including the reaction temperature, the weight ratio of material, reaction time and solvent on the yield. Results The effect of reaction temperature on the reaction yield is the most significant, followed by reaction time; the weight ratio of material and solvent on the yield impact is not obvious. Conclusion The new technology has several advantages and yields up to about 50%, less reactive impurities, easy post processing.

Orthogonal design optimization in synthesis of novel triazole antifungal compounds as key intermediates

1. Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

2. Department of Medical Statistics, Faculty of Health Service, Second Military Medical University, Shanghai 200433, China

Received Date: 2015-11-20

Rev Recd Date: 2015-12-30

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Abstract: Objective To optimize novel triazole antifungal compounds synthesis of key intermediates. Methods The orthogonal experimental design is used, emphasizing on four factors including the reaction temperature, the weight ratio of material, reaction time and solvent on the yield. Results The effect of reaction temperature on the reaction yield is the most significant, followed by reaction time; the weight ratio of material and solvent on the yield impact is not obvious. Conclusion The new technology has several advantages and yields up to about 50%, less reactive impurities, easy post processing.

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Orthogonal design optimization in synthesis of novel triazole antifungal compounds as key intermediates

doi: 10.3969/j.issn.1006-0111.2016.02.018

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通讯作者: 陈斌, [email protected]

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