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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(2): 138-141,166

FAN Wei, WANG Xudong, CAI Haimin, SUN Liguang, YANG Ling, NIE Suifeng. Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 138-141,166. doi: 10.3969/j.issn.1006-0111.2016.02.011
Citation: FAN Wei, WANG Xudong, CAI Haimin, SUN Liguang, YANG Ling, NIE Suifeng. Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 138-141,166. doi: 10.3969/j.issn.1006-0111.2016.02.011
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Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa

doi: 10.3969/j.issn.1006-0111.2016.02.011

  • No.425 Hospital of PLA, Sanya 572000, China

  • Received Date: 2015-08-11
  • Rev Recd Date: 2016-01-05
  • Objective To investigate the secondary metabolites of the South China Sea spine body sponge Acanthella cavernosa. Methods The acetone extract of A. cavernosa was isolated and purified by repeated column chromatography on silica gel, sephadex LH-20, and high-performance liquid chromatography(HPLC). Structures were determined by spectroscopic analysis and comparison with reported data. Results Nine compounds were isolated. Their structures were determined as kalihinol E(1), kalihinol A(2), 10-epi-kalihinol X(3), 10-epi-kalihinol I(4), 1H-indole-3-carboxylic acid methyl ester(5), 1H-indole-3-carboxylic acid(6), 3-buten-2-one,4-(2,3,6-trimethylphenyl)-(3E)(7), aristolone(8), and 5α, 8α-epidioxy-(22E, 24R)-erost-6, 22-dien-3β-ol(9). Conclusion Compounds 5 to 8 were isolated from the sponge of genus Acanthalla for the first time.
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    [12] Xu Y,Lang JH,Jiao WH,et al. Formamido-diterpenes from the South China Sea Sponge Acanthella cavernosa. Marine drugs,2012,10(12):1445-1458.
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Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa

doi: 10.3969/j.issn.1006-0111.2016.02.011
  • No.425 Hospital of PLA, Sanya 572000, China
  • Received Date: 2015-08-11
  • Rev Recd Date: 2016-01-05

Abstract: Objective To investigate the secondary metabolites of the South China Sea spine body sponge Acanthella cavernosa. Methods The acetone extract of A. cavernosa was isolated and purified by repeated column chromatography on silica gel, sephadex LH-20, and high-performance liquid chromatography(HPLC). Structures were determined by spectroscopic analysis and comparison with reported data. Results Nine compounds were isolated. Their structures were determined as kalihinol E(1), kalihinol A(2), 10-epi-kalihinol X(3), 10-epi-kalihinol I(4), 1H-indole-3-carboxylic acid methyl ester(5), 1H-indole-3-carboxylic acid(6), 3-buten-2-one,4-(2,3,6-trimethylphenyl)-(3E)(7), aristolone(8), and 5α, 8α-epidioxy-(22E, 24R)-erost-6, 22-dien-3β-ol(9). Conclusion Compounds 5 to 8 were isolated from the sponge of genus Acanthalla for the first time.

FAN Wei, WANG Xudong, CAI Haimin, SUN Liguang, YANG Ling, NIE Suifeng. Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 138-141,166. doi: 10.3969/j.issn.1006-0111.2016.02.011
Citation: FAN Wei, WANG Xudong, CAI Haimin, SUN Liguang, YANG Ling, NIE Suifeng. Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 138-141,166. doi: 10.3969/j.issn.1006-0111.2016.02.011
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