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Volume 34 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(2): 116-118,173

BI Shuang, HU Dandan, JIANG Yuanying, WANG Yan. The high adaptability and metabolism of Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 116-118,173. doi: 10.3969/j.issn.1006-0111.2016.02.006
Citation: BI Shuang, HU Dandan, JIANG Yuanying, WANG Yan. The high adaptability and metabolism of Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 116-118,173. doi: 10.3969/j.issn.1006-0111.2016.02.006
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The high adaptability and metabolism of Candida albicans

doi: 10.3969/j.issn.1006-0111.2016.02.006

  • New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2015-08-23
  • Rev Recd Date: 2015-09-29
  • Pathogenic Candida albicans has a high degree of adaptability to environment, which is evidenced by its adaptability to various conditions, including its symbiosis with the host, growth in host tissues during invasion, and survival under antifungal treatment. The growth and reproduction of C. albicans is accompanied with metabolism process. C. albicans can use a wide range of carbon and nitrogen sources, and it is sensitive to the alteration of nutrition. Recent studies reveal that the environment affects the metabolism of C. albicans, whilst C. albicans regulates its metabolism to adapt to the environment. Therefore, further study on the relationship between metabolism and high adaptability of C. albicans is helpful to discover novel antifungal targets.
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    [13] Kemsawasd V, Viana T, Ardo Y, et al. Influence of nitrogen sources on growth and fermentation performance of different wine yeast species during alcoholic fermentation[J]. Appl Microbiol Biotechnol, 2015.
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    [17] Brown AJ, Brown GD, Netea MG, et al. Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels[J]. Trends Microbiol, 2014, 22(11):614-622.
    [18] Vieira N, Casal M, Johansson B, et al. Functional specialization and differential regulation of short-chain carboxylic acid transporters in the pathogen Candida albicans[J]. Mol Microbiol, 2010, 75(6):1337-1354.
    [19] Kitahara N, Morisaka H, Aoki W, et al. Description of the interaction between Candida albicans and macrophages by mixed and quantitative proteome analysis without isolation[J]. Amb Express, 2015, 5(1):127.
    [20] Ramirez MA, Lorenz MC. Mutations in alternative carbon utilization pathways in Candida albicans attenuate virulence and confer pleiotropic phenotypes[J]. Eukaryot Cell, 2007, 6(2):280-290.
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    [22] Dunkel N, Biswas K, Hiller E, et al. Control of morphogenesis, protease secretion and gene expression in Candida albicans by the preferred nitrogen source ammonium[J]. Microbiology, 2014, 160(Pt 8):1599-1608.
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The high adaptability and metabolism of Candida albicans

doi: 10.3969/j.issn.1006-0111.2016.02.006
  • New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2015-08-23
  • Rev Recd Date: 2015-09-29

Abstract: Pathogenic Candida albicans has a high degree of adaptability to environment, which is evidenced by its adaptability to various conditions, including its symbiosis with the host, growth in host tissues during invasion, and survival under antifungal treatment. The growth and reproduction of C. albicans is accompanied with metabolism process. C. albicans can use a wide range of carbon and nitrogen sources, and it is sensitive to the alteration of nutrition. Recent studies reveal that the environment affects the metabolism of C. albicans, whilst C. albicans regulates its metabolism to adapt to the environment. Therefore, further study on the relationship between metabolism and high adaptability of C. albicans is helpful to discover novel antifungal targets.

BI Shuang, HU Dandan, JIANG Yuanying, WANG Yan. The high adaptability and metabolism of Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 116-118,173. doi: 10.3969/j.issn.1006-0111.2016.02.006
Citation: BI Shuang, HU Dandan, JIANG Yuanying, WANG Yan. The high adaptability and metabolism of Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 116-118,173. doi: 10.3969/j.issn.1006-0111.2016.02.006
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