Research progress of structural modification of oridonin

LIU Hongchuan; JIN Yongsheng; CHEN Haisheng

doi:10.3969/j.issn.1006-0111.2016.02.005

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Oridonin is an en-kaurene diterpenoids compound which was found to have effect on tumor in vitro. But the clinical application has been limited because of poor water solubility, low bioavailability and oral absorption. Many scholars conducted a large number of structure modification researches of oridonin to search for new diterpenes with higher bio-activities and better bio-availabilities, and to develop new antitumor drugs. In this paper, studies on this aspect of oridonin were reviewed.

Research progress of structural modification of oridonin

1. Department of Pharmacy, Beijing ChaoYang Hospital Affiliated to Capital Medical University, Beijing 100020, China

2. Department of Organic Chemistry, Second Military Medical University, Shanghai 200433, China

3. Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2014-07-24

Rev Recd Date: 2014-12-09

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Abstract: Oridonin is an en-kaurene diterpenoids compound which was found to have effect on tumor in vitro. But the clinical application has been limited because of poor water solubility, low bioavailability and oral absorption. Many scholars conducted a large number of structure modification researches of oridonin to search for new diterpenes with higher bio-activities and better bio-availabilities, and to develop new antitumor drugs. In this paper, studies on this aspect of oridonin were reviewed.

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Research progress of structural modification of oridonin

doi: 10.3969/j.issn.1006-0111.2016.02.005

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通讯作者: 陈斌, [email protected]

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