WANG Wei, CHENG Minghe, GAO Jing, ZHANG Xiaojie. Study on hemostasis of Bletillastriata hemostatic sponge[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 32-35,65. doi: 10.3969/j.issn.1006-0111.2016.01.009
| Citation:
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WANG Wei, CHENG Minghe, GAO Jing, ZHANG Xiaojie. Study on hemostasis of Bletillastriata hemostatic sponge[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 32-35,65. doi: 10.3969/j.issn.1006-0111.2016.01.009
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Study on hemostasis of Bletillastriata hemostatic sponge
- 1.
No. 455 Hospital of PLA, Shanghai 200052, China
- 2.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- 3.
Medical Material Supply Station of Fengtai Warehouse, General Logistics Department of the PLA, Beijing 100071, China
- Received Date: 2015-02-12
- Rev Recd Date:
2015-06-02
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Abstract
Objective To investigate the hemostatic effect of Bletillastriata hemostatic sponge. Methods Tail hemorrhage model in rats was preparation. Another model was established in liver and spleen hemorrhagic model of rabbits, Beagle dog's abdominal aorta and liver were made. Hemostasis was performed with medical gauze, gelatin sponge and Bletillastriata hemostatic sponge. The hemostatic effects were evaluated by total blood loss, hemostatic time and histological observation. Observation of Bletillastriata hemostatic sponge change was completed to determine their degradation in the bodies. Results Rats tail hemorrhage was clamped, after 1 min, Bletillastriata hemostatic sponge could effectively stop the bleeding.The Bletillastriata hemostatic sponge has good hemostatic effect of rats tail hemorrhage model compared to blank group(P<0.01). Compare with the gelatin sponge group, the Bletillastriata hemostatic sponge could significantly shorten the liver and spleen bleeding time(P<0.05), decrease the volume of the spleen bleeding(P<0.05) and the liver bleeding(P<0.01), in hemorrhagic model of rabbits. Compared with the gelatin sponge group, Bletillastriata hemostatic sponge could more effectively stop the bleeding in the abdominal aorta and liver model of Beagle dogs (P<0.05). The Bletillastriata hemostatic sponge could be degraded in vivo. Histologic study revealed the Bletillastriata hemostatic sponge was no significant pathological change around the liver and spleen. Conclusion The Bletillastriata hemostatic sponge has good hemostatic effect. The hemostatic effect of Bletillastriata hemostatic sponge is better than gelatin sponge, which could be a good topical hemostatic material.
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