CHEN Lina, CHEN Jianming. The influence of log P value of insoluble drugs on drug-loading properties of nano-lipid emulsion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 513-517. doi: 10.3969/j.issn.1006-0111.2015.06.009
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CHEN Lina, CHEN Jianming. The influence of log P value of insoluble drugs on drug-loading properties of nano-lipid emulsion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 513-517. doi: 10.3969/j.issn.1006-0111.2015.06.009
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The influence of log P value of insoluble drugs on drug-loading properties of nano-lipid emulsion
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Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- Received Date: 2015-06-08
- Rev Recd Date:
2015-10-08
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Abstract
Objective To study the influence on common logarithm of partition-coefficient (log P) value of insoluble drugs on nano-lipid emulsion properties, including drug-loading amount, in vitro release, and phase distribution etc. Methods 6 insoluble drugs, nimodipine (NIM), docetaxel (DTX), curcumin (CUR), paclitaxel (PTX), teniposide (TEN), silybin (SLB), were selected as the model drugs, to investigate the relationship between log P value and nano-lipid emulsion of the dissolubility in PEG400, the amount of drug-loading, particle diameter, Zeta potential, in vitro release, and phase distribution respectively. Results With the increase of log P value, drug solubility in PEG400 first increased and then decreased, drug-loading in nano-lipid emulsion increased, release rate in vitro of drug slowed down, drug distribution in oil phase increased while in emulsion layer decreased. Log P value has no correlation with particle diameter and Zeta potential. Conclusion The properties of drug-loading nano-lipid emulsion can be preliminarily judged by log P values and the solubility in PEG400 of drugs.
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