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XUE Xiaochun, HU Jinhong. Research methods and applications in network pharmacology[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 401-405. doi: 10.3969/j.issn.1006-0111.2015.05.005
Citation: XUE Xiaochun, HU Jinhong. Research methods and applications in network pharmacology[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 401-405. doi: 10.3969/j.issn.1006-0111.2015.05.005

Research methods and applications in network pharmacology

doi: 10.3969/j.issn.1006-0111.2015.05.005
  • Received Date: 2014-08-31
  • Rev Recd Date: 2014-11-26
  • Recently, network pharmacology was a pop emerging pharmacology branch. The theory of "multi-gene, multi-target" about network pharmacology was consistent with treatment of complex disease. Different from the traditional experimental methods about pharmacology, the research methods of network pharmacology uniquely obtain the information of drugs and relative targets with less time and less money. In this paper, according to the searching of China Knowledge Resource Integrated Database and PubMed, three aspects about research methods of network pharmacology together with its applications were introduced: network construction, network analysis and experimental validation. The introductions of the methods gave us a new vision in researching the field of pharmacology deeply.
  • [1] Hopkins AL. Network pharmacology[J]. Nat Biotechnol, 2007, 25(10):1110-1111.
    [2] Hopkins AL. Network pharmacology: the next paradigm in drug discovery[J]. Nat Chem Biol, 2008, 4(11):682-690.
    [3] Barabasi AL, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease[J].Nat Rev Genet,2011,12(1):56-68.
    [4] Satoh JI. Molecular network of microRNA targets in Alzheimer's disease brains[J].Exp Neurol,2012,235(2):436-446.
    [5] Lopes CT, Franz M, Kazi F, et al. Cytoscape web: an interactive web-based network browser[J]. Bioinformatics, 2010,26(18):2347-2348.
    [6] 周文霞,程肖蕊,张永样. 网络药理学:认识药物及发现药物的新理念[J].中国药理学与毒理学杂志,2012,26(1):4-9.
    [7] Li S, Zhang B. Traditional Chinese medicine network pharmacology: theory, methodology and application[J].Chin J Nat Med,2013,11(2):110-120.
    [8] Azmi AS. Adopting network pharmacology for cancer drug discovery[J]. Curr Drug Discov Technol, 2013, 10(2): 95-105.
    [9] Yang M, Chen JL, Xu LW, et al. Navigating traditional Chinese medicine network pharmacology and computational tools[J]. Evid Based Complement Alternat Med, 2013, 2013: 731969.
    [10] Li S, Zhang B, Jiang D, et al. Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae[J]. BMC Bioinformatics, 2010, 11(suppl 11):S6.
    [11] 张新庄,萧 伟,徐筱杰,等.利用网络药理学方法研究热毒宁注射液抗流感病毒的分子作用机制[J].物理化学学报,2013,29(7):1415-1420.
    [12] Sheng SJ, Wang JX, Wang LR, et al. Network pharmacology analyses of the antithrombotic harmacological mechanism of Fufang Xueshuantong Capsule with experimental support using disseminated intravascular coagulation rats[J]. J Ethnopharmacol, 2014, 154(3): 735-744.
    [13] Zheng CL, Wang JN, Liu JL, et al. System-level multi-target drug discovery from natural products with applications to cardiovascular diseases[J].Mol Divers,2014,18(3): 621-635.
    [14] Li HY, Zhao LH, Zhang B, et al. A network pharmacology approach to determine active compounds and action mechanisms of ge-gen-qin-lian decoction for treatment of type 2 diabetes[J]. Evid Based Complement Alternat Med,2014,2014:495840.
    [15] Fan X, Shi L, Fang H, et al. DNA microarrays are predictive of cancer prognosis: a reevaluation[J]. Clin Cancer Res, 2010, 16(2): 629-636.
    [16] Engin HB, Keskin O, Nussinov R, et al. A strategy based on protein-protein interface motifs may help in identifying drug off-targets[J]. J Chem Inf Model, 2012, 52(8): 2273-2286.
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Research methods and applications in network pharmacology

doi: 10.3969/j.issn.1006-0111.2015.05.005

Abstract: Recently, network pharmacology was a pop emerging pharmacology branch. The theory of "multi-gene, multi-target" about network pharmacology was consistent with treatment of complex disease. Different from the traditional experimental methods about pharmacology, the research methods of network pharmacology uniquely obtain the information of drugs and relative targets with less time and less money. In this paper, according to the searching of China Knowledge Resource Integrated Database and PubMed, three aspects about research methods of network pharmacology together with its applications were introduced: network construction, network analysis and experimental validation. The introductions of the methods gave us a new vision in researching the field of pharmacology deeply.

XUE Xiaochun, HU Jinhong. Research methods and applications in network pharmacology[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 401-405. doi: 10.3969/j.issn.1006-0111.2015.05.005
Citation: XUE Xiaochun, HU Jinhong. Research methods and applications in network pharmacology[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 401-405. doi: 10.3969/j.issn.1006-0111.2015.05.005
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