Research on the technological process and methods of the comprehensive pharmaceutical experiment of rutin tablets

CHEN Li; DU Hongli; ZENG Rentao; ZHANG Yeye; LU Ying; CAI Guojun

doi:10.3969/j.issn.1006-0111.2015.04.018

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Objective To imitate the development process of new drugs with rutin as the model and to do multidisciplinary experiments of preparation and pharmacodynamics of rutin tablets. Methods Thin-layer chromatography was used to identify rutin in Pagodatree flower bud. High-performance liquid chromatography was used for quantitative determination of rutin in Pagodatree flower bud and rutin products. The vasodilatation effect of rutin was investigated. The preparation of rutin tablets was completed. Results and Conclusion We completed the identification of Pagodatree flower bud, extraction and purification of rutin from Pagodatree flower bud, the assay of rutin, the pharmaco-dynamics study and the formulation of rutin tablets. The experiments helped the postgraduates to be familiar with the research process of new drugs and to improve their experimental operation skills.

Research on the technological process and methods of the comprehensive pharmaceutical experiment of rutin tablets

School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2014-06-25

Rev Recd Date: 2015-01-12

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Abstract: Objective To imitate the development process of new drugs with rutin as the model and to do multidisciplinary experiments of preparation and pharmacodynamics of rutin tablets. Methods Thin-layer chromatography was used to identify rutin in Pagodatree flower bud. High-performance liquid chromatography was used for quantitative determination of rutin in Pagodatree flower bud and rutin products. The vasodilatation effect of rutin was investigated. The preparation of rutin tablets was completed. Results and Conclusion We completed the identification of Pagodatree flower bud, extraction and purification of rutin from Pagodatree flower bud, the assay of rutin, the pharmaco-dynamics study and the formulation of rutin tablets. The experiments helped the postgraduates to be familiar with the research process of new drugs and to improve their experimental operation skills.

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Research on the technological process and methods of the comprehensive pharmaceutical experiment of rutin tablets

doi: 10.3969/j.issn.1006-0111.2015.04.018

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通讯作者: 陈斌, [email protected]

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