The effects of sevofluraneon learning and memory of neonatal mice

SUN Jihui; LU Zhijun; Xin Yichun; Yu Buwei

doi:10.3969/j.issn.1006-0111.2015.04.014

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Objective To evaluate the effects of sevoflurane on learning and memory of neonatal mice. Methods 122 neonatalmice (7 days postnatal) were included in this study.72 of them were exposed to sevoflurane (1.0 or 0.5MAC,minimum alveolar concentration) or 40% O₂ for 2 h(hours). Morris water maze was performed 4 and 12 weeks after anesthesia. Latency and swimming speed during training, time on island and times across island during the research were recorded. The rest 50 mice was used in artery blood analysis during sevoflurane (1.0 or 0.5 MAC, 0,1,2 h). Results pH,PaO₂, PaCO₂, SaO₂ were stable during anesthesia. Latency in control group were significantly shorter than the two anesthesia groups 4 weeks after anesthesia and 3 days after the training. During the last 2 training days, the latency in 1.0 MAC sevoflurane-exposed mice were significantly longer than that of the 0.5 MAC group.12 weeks after anesthesia, the latency was still significantly longer in 1.0 MAC sevoflurane-exposed mice on the last training day. The time on island and/or times across island were significantly decreased in anesthesia groupsduring theresearch performed 4 weeks and 12 weeks after anesthesia. Conclusion Early exposure to sevoflurane leads to a concentration and time-depended persistent learning and memory deficits to neonatal mice.

The effects of sevofluraneon learning and memory of neonatal mice

1. School of Medicine, Tongji University, Shanghai 200092, China

2. Department of Anesthesia, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China

3. Department of Anesthesia, Luwan Branch of Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200020, China

Received Date: 2014-06-04

Rev Recd Date: 2014-10-27

Key words:

Abstract: Objective To evaluate the effects of sevoflurane on learning and memory of neonatal mice. Methods 122 neonatalmice (7 days postnatal) were included in this study.72 of them were exposed to sevoflurane (1.0 or 0.5MAC,minimum alveolar concentration) or 40% O₂ for 2 h(hours). Morris water maze was performed 4 and 12 weeks after anesthesia. Latency and swimming speed during training, time on island and times across island during the research were recorded. The rest 50 mice was used in artery blood analysis during sevoflurane (1.0 or 0.5 MAC, 0,1,2 h). Results pH,PaO₂, PaCO₂, SaO₂ were stable during anesthesia. Latency in control group were significantly shorter than the two anesthesia groups 4 weeks after anesthesia and 3 days after the training. During the last 2 training days, the latency in 1.0 MAC sevoflurane-exposed mice were significantly longer than that of the 0.5 MAC group.12 weeks after anesthesia, the latency was still significantly longer in 1.0 MAC sevoflurane-exposed mice on the last training day. The time on island and/or times across island were significantly decreased in anesthesia groupsduring theresearch performed 4 weeks and 12 weeks after anesthesia. Conclusion Early exposure to sevoflurane leads to a concentration and time-depended persistent learning and memory deficits to neonatal mice.

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Reference (19)

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The effects of sevofluraneon learning and memory of neonatal mice

doi: 10.3969/j.issn.1006-0111.2015.04.014

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