Identification of Norvasc and counterfeit drugs based on Raman spectra of pharmaceutical excipients

QIAN Xiaofeng; LIU Yan; CHEN Hui; LU Feng

doi:10.3969/j.issn.1006-0111.2015.04.012

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Objective To build an identification method for Norvascand its counterfeit drugs based on the differences of their pharmaceutical excipients with the original and generic Amlodipine besylatetablets as tools. Methods Raman spectra of pharmaceutical excipients which were usually used in tablets were collected.Similarity algorithm and characteristic Raman bands were used to search the excipients contained in the tablets. If the excipients was not the same as excipients contained in Norvasc, the tablet was judged as counterfeit drugs. Otherwise, principal component analysis was used to identify counterfeit and generic. Results and conclusion The method based on Raman spectra of pharmaceutical excipients could identify Norvasc and counterfeit drugs efficiently and accurately.

Identification of Norvasc and counterfeit drugs based on Raman spectra of pharmaceutical excipients

Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2014-07-09

Rev Recd Date: 2015-01-14

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Abstract: Objective To build an identification method for Norvascand its counterfeit drugs based on the differences of their pharmaceutical excipients with the original and generic Amlodipine besylatetablets as tools. Methods Raman spectra of pharmaceutical excipients which were usually used in tablets were collected.Similarity algorithm and characteristic Raman bands were used to search the excipients contained in the tablets. If the excipients was not the same as excipients contained in Norvasc, the tablet was judged as counterfeit drugs. Otherwise, principal component analysis was used to identify counterfeit and generic. Results and conclusion The method based on Raman spectra of pharmaceutical excipients could identify Norvasc and counterfeit drugs efficiently and accurately.

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Reference (7)

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Identification of Norvasc and counterfeit drugs based on Raman spectra of pharmaceutical excipients

doi: 10.3969/j.issn.1006-0111.2015.04.012

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通讯作者: 陈斌, [email protected]

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