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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(3): 263-268

TIAN Huaiping, GAO Huimin, ZHANG Jinlian, TANG Yuenian. Lamotrigine for absence seizures in children and adolescents: a systematic review[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 263-268. doi: 10.3969/j.issn.1006-0111.2015.03.020
Citation: TIAN Huaiping, GAO Huimin, ZHANG Jinlian, TANG Yuenian. Lamotrigine for absence seizures in children and adolescents: a systematic review[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 263-268. doi: 10.3969/j.issn.1006-0111.2015.03.020
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Lamotrigine for absence seizures in children and adolescents: a systematic review

doi: 10.3969/j.issn.1006-0111.2015.03.020
  • 1.

    Pharmacy of Department, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

  • 2.

    Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

  • Received Date: 2014-11-17
  • Rev Recd Date: 2015-01-04
  • Objective To assess the efficacy and safety of lamotrigine for absence seizures in children and adolescents. Methods Databases of PubMed, the Cochrane Library, EMbase, CENTRAL, VIP, WanFang, CBM and CNKI were electronically searched till August, 2014 for clinical trials on lamotrigine for absence seizures in children and adolescents. All literature were screened by two reviewers independently according to the inclusion and exclusion criteria.The data was extracted, and the methodological quality was assessed. Then, meta-analysis was performed using RevMan 5.2. Results Seven trials were included involving a total of 721 patients. The Results of methodological qualities were two studies rated as A-class, three studies rated as B-class and two studies rated as C-class. Meta-analysis Results showed that the efficacy of lamotrigine monotherapy for absence seizure in children and adolescents was better than placebo, but efficacy of lamotrigine was lower than valproic acid and ethosuximide. The adverse reaction rates of lamotrigine were with no significant difference compared with valproic acid and ethosuximide. Conclusion Lamotrigine monotherapy was effective for absence seizures in children and adolescents and was well tolerated. Lamotrigine was a good choice for patients that are intolerable to valproic acid or ethosuximide.
  • [1] Commission on classification and terminology of the international league against epilepsy.Proposal for revised classification of epilepsies and epileptic syndromes[J].Epilepsia,1989,30( 4) :389-399.
    [2] 周 东, 吴欣桐,刘 凌, 等. "国际抗癫痫联盟关于单药治疗癫痫发作及癫痫综合症治疗指南"简介[J].中华神经科杂志, 2007, 40(3):207-209.
    [3] Holmes GL, Frank LM, Sheth RD,et al.Lamotrigine monotherapy for newly diagnosed typical absence seizures in children[J].Epilepsy Res, 2008, 82(2-3):124-132.
    [4] Posner EB, Mohamed KK, Marson AG. Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents (Review)[J]. Cochrane Library, 2005, 4:CD003032.
    [5] Glauser T,Ben-Menachem E,Bourgeois B, et al.Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes[J].Epilepsia, 2013, 54( 3) : 551-563.
    [6] Vanessa Delgado Nunes, Laura Sawyer, Julie Neilson,et al.Guidelines: diagnosis andmanagement of the epilepsies in adults and children: summary of updated NICE guidance[J].BMJ, 2012, 344(7842): e281.
    [7] Higgins JPT, Grenn S. Cochrane handbook for systematic reviews of interventions version 5.1.0[M].London:The Cochrane Collaboration,2011.
    [8] Frank LM, EnlowT, Gregory L, et al.Lamictal (lamotrigine) monotherapy for typical absence seizures in children[J].Epilepsia, 1999, 40(7):973-979.
    [9] Coppola G, Auricchio G, Federico R,et al.Lamotrigine versus valproic acid as first-line monotherapy in newly diagnosed typical absence seizures an open-label, randomized, parallel-group study[J].Epilepsia, 2004, 45(9):1049-1053.
    [10] 黄铁栓, 朱金兰, 李 冰, 等. 丙戊酸和拉莫三嗪治疗儿童失神癫痫的临床研究[J].中国当代儿科杂志, 2009, 11(8):653-655.
    [11] 张言春. 拉莫三嗪治疗儿童失神癫痫的疗效研究[J].中国社区医师, 2012, 27(14):101.
    [12] Glauser TA, Cnaan A, ShinnarS,et al.Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy initial monotherapy outcomes at 12 months[J].Epilepsia, 2013,54(1):141-155.
    [13] 范 磊, 陈海燕. 乙琥胺与拉莫三嗪治疗儿童失神性癫痫的疗效比较[J].中国现代药物应用, 2013, 7(13):161-162.
    [14] Buoni S, Grosso S,Fois A.Lamotrigine in typical absence epilepsy[J].Brain Devel, 1999, 21 (5):303-306.
    [15] Pressler RM, Binnie CD, Coleshill SG, et al.Effect of lamotrigine on cognition in children with epilepsy[J].Neurology, 2006, 66(10):1495-1499.
    [16] 杨米凤, 肖 农. 拉莫三嗪单药治疗2~12岁儿童癫痫及其对认知功能影响的研究进展[J].儿科药学杂志, 2014, 20(7):57-60.
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Lamotrigine for absence seizures in children and adolescents: a systematic review

doi: 10.3969/j.issn.1006-0111.2015.03.020
  • 1. Pharmacy of Department, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • 2. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received Date: 2014-11-17
  • Rev Recd Date: 2015-01-04

Abstract: Objective To assess the efficacy and safety of lamotrigine for absence seizures in children and adolescents. Methods Databases of PubMed, the Cochrane Library, EMbase, CENTRAL, VIP, WanFang, CBM and CNKI were electronically searched till August, 2014 for clinical trials on lamotrigine for absence seizures in children and adolescents. All literature were screened by two reviewers independently according to the inclusion and exclusion criteria.The data was extracted, and the methodological quality was assessed. Then, meta-analysis was performed using RevMan 5.2. Results Seven trials were included involving a total of 721 patients. The Results of methodological qualities were two studies rated as A-class, three studies rated as B-class and two studies rated as C-class. Meta-analysis Results showed that the efficacy of lamotrigine monotherapy for absence seizure in children and adolescents was better than placebo, but efficacy of lamotrigine was lower than valproic acid and ethosuximide. The adverse reaction rates of lamotrigine were with no significant difference compared with valproic acid and ethosuximide. Conclusion Lamotrigine monotherapy was effective for absence seizures in children and adolescents and was well tolerated. Lamotrigine was a good choice for patients that are intolerable to valproic acid or ethosuximide.

TIAN Huaiping, GAO Huimin, ZHANG Jinlian, TANG Yuenian. Lamotrigine for absence seizures in children and adolescents: a systematic review[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 263-268. doi: 10.3969/j.issn.1006-0111.2015.03.020
Citation: TIAN Huaiping, GAO Huimin, ZHANG Jinlian, TANG Yuenian. Lamotrigine for absence seizures in children and adolescents: a systematic review[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 263-268. doi: 10.3969/j.issn.1006-0111.2015.03.020
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