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Volume 33 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(3): 242-245,274

FANG Fengkai, TANG Hua, LIU Baoshu, ZHUANG Chunlin, SUN Peng, ZHANG Wen. Study on chemical constitunts of sponge Agelas mauritiana from the South China Sea[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 242-245,274. doi: 10.3969/j.issn.1006-0111.2015.03.013
Citation: FANG Fengkai, TANG Hua, LIU Baoshu, ZHUANG Chunlin, SUN Peng, ZHANG Wen. Study on chemical constitunts of sponge Agelas mauritiana from the South China Sea[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 242-245,274. doi: 10.3969/j.issn.1006-0111.2015.03.013
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Study on chemical constitunts of sponge Agelas mauritiana from the South China Sea

doi: 10.3969/j.issn.1006-0111.2015.03.013

  • Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2015-03-05
  • Rev Recd Date: 2015-04-16
  • Objective To investigate the chemical constituents of marine sponge Agelas mauritiana collected from the South China Sea. Methods The n-butanol extract of marine sponge Agelas mauritiana was separated and purified by repeated column chromatography on silica gel, Sephadex LH-20, and reversed-phase high-performance liquid chromatography (RP-HPLC). The chemical structures of those obtained compounds were determined on the basis of spectroscopic analysis and comparison with reported data. The tumor cell growth inhibitory activity of these compounds towards human lung carcinoma cells A549 was tested. Results Eight compounds were isolated, including agelasine A ( 1 ), agelasine B ( 2 ), epi-agelasine C ( 3 ), (-)agelasine D ( 4 ), agelasine E ( 5 ), agelasine F ( 6 ), (-)ageloxime D ( 7 ) and aurantiamide acetate ( 8 ). These compounds displayed different level of tumor cell growth inhibitory activity towards cell A549 in vitro. Compounds 1 - 3 showed significant activity towards cell A549, being similar to that of the positive control of adriamycin. Conclusion Compounds 1 , 2 , 4 , 5 , 6 , 8 were isolated for the first time from the sponge Agelas mauritiana. Cell A549 was selected for the first time for the activity evaluation of compounds 1 ~ 7 .Significant inhibition activity of compounds 2 、 3 may hold as a basis for further research.
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    [2] Yasuda T, Araki A, Kubota T, et al. Bromopyrrole alkaloids from marine sponges of the genus Agelas[J]. J Nat Prod, 2009, 72(3): 488-491.
    [3] Putra MY, Jaswir I. The alkaloids from Indonesian marine sponges[J]. Oceanography, 2014, 2(2): 1-10.
    [4] Costantino V, Fattorusso E, Mangoni A. Glycolipids from sponges, I. Glycosyl ceramide composition of the marine sponge Agelas clathrodes[J]. Eur J Org Chem, 1995, (8): 1471-1475.
    [5] Tsukamoto S, Kato H, Hirota H, et al. Mauritiamine, a new antifouling oroidin dimer from the marine sponge Agelas mauritiana[J]. J Nat Prod, 1996, 59 (5): 501-503.
    [6] Kondracki1 MLB, Kornprobst JM. Marine pharmacology: potentialities in the treatment of infectious diseases, osteoporosis and alzheimer's disease[J]. Adv Biochem Eng/Biotechnol, 2005, 97(2): 105-131.
    [7] Tanaka Y, Soejima T, Katayama T. Biochemical studies of the carotenoids in porifera distribution of the carotenoids in porifera[J]. Bull Jpn Soc Sci Fish, 1978, 44(11): 1283-1285.
    [8] Wu HM, Nakamura H, Kobayashi J,et al. Structures of agelasines, diterpenes having a 9-methyladeninium chromophore isolated from the Okinawan marine sponge Agelas nakamurai Hoshino[J]. Bull Chem Soc Jpn, 1986, 59 (8): 2495-2504.
    [9] Hattori T, Adachi K, Shizuri Y. New agelasine compound from the marine sponge Agelas mauritiana as an antifouling substance against macroalgae[J]. J Nat Prod, 1997, 60 (4): 411-413.
    [10] Hertiani T,Ebel RE, Ortlepp S, et al. From anti-fouling to biofilm inhibition: new cytotoxic secondary metabolites from two Indonesian Agelas sponges[J]. Bioorg Med Chem, 2010, 18 (3): 1297-1311.
    [11] Wu HM, Nakamura H, Kobayashi J, et al. Agelasine E and F, novel monocyclic diterpenoids with a 9-methyladeninium unit possessing inhibitory effects on Na,K-ATPase isolated from the Okinawan sea sponge Agelas nakamurai Hoshino[J]. Tetrahedron Lett, 1984, 25(34): 3719-3722.
    [12] Wang S, Jiang Y, Zeng KW, et al. Antineuroinflammatory constituents from Artemisia argyi[J]. J Chin Pharm Sci, 2013, 22 (4): 377-380.
    [13] Dosumu OO, Onocha P, Ekundayo O, et al. Isolation of aurantiamides from Gomphrena celosioides C. Mart[J]. J Pharm Res, 2014, 13 (1): 143-147.
    [14] Stone V, Shaw J, Brown DM, et al. The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function[J]. Toxicol Vitro, 1998, 12(6): 649-659.
    [15] 王明焱,陆伟刚,曾陇梅,等. 莳萝曲网海绵化学成分的研究[J]. 应用化学, 2002, 19(1):1-3.
    [16] Hertiani T. Isolation and structure elucidation of bioactive secondary metabolites from Indonesian marine sponges[D]. Düsseldorf: Gedruckt mit Unterstützung des Deutschen Akademischen Austauschdienstes, 2007: 149-150.
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Study on chemical constitunts of sponge Agelas mauritiana from the South China Sea

doi: 10.3969/j.issn.1006-0111.2015.03.013
  • Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2015-03-05
  • Rev Recd Date: 2015-04-16

Abstract: Objective To investigate the chemical constituents of marine sponge Agelas mauritiana collected from the South China Sea. Methods The n-butanol extract of marine sponge Agelas mauritiana was separated and purified by repeated column chromatography on silica gel, Sephadex LH-20, and reversed-phase high-performance liquid chromatography (RP-HPLC). The chemical structures of those obtained compounds were determined on the basis of spectroscopic analysis and comparison with reported data. The tumor cell growth inhibitory activity of these compounds towards human lung carcinoma cells A549 was tested. Results Eight compounds were isolated, including agelasine A ( 1 ), agelasine B ( 2 ), epi-agelasine C ( 3 ), (-)agelasine D ( 4 ), agelasine E ( 5 ), agelasine F ( 6 ), (-)ageloxime D ( 7 ) and aurantiamide acetate ( 8 ). These compounds displayed different level of tumor cell growth inhibitory activity towards cell A549 in vitro. Compounds 1 - 3 showed significant activity towards cell A549, being similar to that of the positive control of adriamycin. Conclusion Compounds 1 , 2 , 4 , 5 , 6 , 8 were isolated for the first time from the sponge Agelas mauritiana. Cell A549 was selected for the first time for the activity evaluation of compounds 1 ~ 7 .Significant inhibition activity of compounds 2 、 3 may hold as a basis for further research.

FANG Fengkai, TANG Hua, LIU Baoshu, ZHUANG Chunlin, SUN Peng, ZHANG Wen. Study on chemical constitunts of sponge Agelas mauritiana from the South China Sea[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 242-245,274. doi: 10.3969/j.issn.1006-0111.2015.03.013
Citation: FANG Fengkai, TANG Hua, LIU Baoshu, ZHUANG Chunlin, SUN Peng, ZHANG Wen. Study on chemical constitunts of sponge Agelas mauritiana from the South China Sea[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 242-245,274. doi: 10.3969/j.issn.1006-0111.2015.03.013
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