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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(3): 217-220

WEI Pingyan, YUAN Wang, YANG Feng, CUI Lili. The preparation of electret fluorouracil gel patch[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 217-220. doi: 10.3969/j.issn.1006-0111.2015.03.007
Citation: WEI Pingyan, YUAN Wang, YANG Feng, CUI Lili. The preparation of electret fluorouracil gel patch[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 217-220. doi: 10.3969/j.issn.1006-0111.2015.03.007
shu

The preparation of electret fluorouracil gel patch

doi: 10.3969/j.issn.1006-0111.2015.03.007
  • 1.

    Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China

  • 2.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 3.

    Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2014-07-03
  • Rev Recd Date: 2015-01-23
  • Objective To study and optimize the preparation process and abserve the related properties of electret fluorouracil gel patch. Methods the adhesives and moistening agents were screened by preliminary experiment. The optimal matrix proportion in the blank gel patch was obtained with orthogonal design. The charge storage stability of the patch was studied by compensation method. The transdermal behaviors of the patch were evaluated by modified diffusion cell method and HPLC. Results The optimal matrix proportions of PAAS:gelatin:PVA:Kaolin:CMC-Na:moistening agents were 0.2:0.7:0.5:0.7:0.2:12.The patch had a good charge storage stability. All the electrets and 3% azone could enhance the cumulative penetration amount of drug and they had synergistic enhancing effect. Conclusion The qualified electret fluorouracil gel patch was prepared under the optimal process, which had no skin irritation and the behavior of transdermal delivery was better than that of the traditional gel patch.
  • [1] 连佳芳, 张三奇. 5-氟尿嘧啶剂型研究进展[J]. 西北药学杂志, 2005, 20(5): 238-240.
    [2] 夏钟福. 驻极体[M]. 北京: 科学出版社, 2001: 2-7.
    [3] Jiang J, Dong FJ, Liang YY, et al.Penetration and stability of external electrostatic field of ppelectret through rat skin[J]. IEEE transactions on dielectrics and electrical insulation, 2012,19(4):1137-1142.
    [4] 赵 颖, 林亚平. 雪上一枝蒿巴布剂的研制[J]. 重庆中草药研究, 2005, (1): 29-31.
    [5] 奚 炜, 胡晋红, 朱全刚,等. 正交设计法优化巴布剂基质处方[J]. 药学服务与研究, 2004, 4(1): 80-82.
    [6] 国家药典委员会.中华人民共和国药典 2010年版一部[S]. 北京: 中国医药科技出版社, 2010: 附录74.
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The preparation of electret fluorouracil gel patch

doi: 10.3969/j.issn.1006-0111.2015.03.007
  • 1. Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
  • 2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 3. Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2014-07-03
  • Rev Recd Date: 2015-01-23

Abstract: Objective To study and optimize the preparation process and abserve the related properties of electret fluorouracil gel patch. Methods the adhesives and moistening agents were screened by preliminary experiment. The optimal matrix proportion in the blank gel patch was obtained with orthogonal design. The charge storage stability of the patch was studied by compensation method. The transdermal behaviors of the patch were evaluated by modified diffusion cell method and HPLC. Results The optimal matrix proportions of PAAS:gelatin:PVA:Kaolin:CMC-Na:moistening agents were 0.2:0.7:0.5:0.7:0.2:12.The patch had a good charge storage stability. All the electrets and 3% azone could enhance the cumulative penetration amount of drug and they had synergistic enhancing effect. Conclusion The qualified electret fluorouracil gel patch was prepared under the optimal process, which had no skin irritation and the behavior of transdermal delivery was better than that of the traditional gel patch.

WEI Pingyan, YUAN Wang, YANG Feng, CUI Lili. The preparation of electret fluorouracil gel patch[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 217-220. doi: 10.3969/j.issn.1006-0111.2015.03.007
Citation: WEI Pingyan, YUAN Wang, YANG Feng, CUI Lili. The preparation of electret fluorouracil gel patch[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 217-220. doi: 10.3969/j.issn.1006-0111.2015.03.007
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