Comparative study of venlafaxine sustained-release capsules and citalopram tablet in the treatment of post-stroke depression

XIA Shiyan; SHEN Zhuanghong; ZHANG Yingran; ZHANG Peng

doi:10.3969/j.issn.1006-0111.2015.02.022

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

Objective To compare the therapeutic effectiveness and safeness of venlafaxine sustained-release capsules and citalopram tablets in the treatment of post-stroke depression. Methods 60 patients were randomly divided into venlafaxine group (n=30)and citalomram group(n=30) for 8 weeks treatment. Hamilton rating scale for depression(HAMD) and treatment emergent system scale (TESS) were used to evaluate the efficacy and side effects, respectively. Results After 4-8 weeks of treatment,both scores of HAMD of the two groups decreased significantly(P<0.05),but there was no difference between the two groups(P>0.05). The total scores of HAMD in venlafaxine group were notably lower than citalopram group after 2 weeks(P<0.05). There was no significant difference in side effects between the two groups(P>0.05). Conclusion There was no significant difference in gross curative effect and side effects between two groups; venlafaxine worked faster compared to citalopram.

Comparative study of venlafaxine sustained-release capsules and citalopram tablet in the treatment of post-stroke depression

1. Xiaoshan Mental Health Centre, Xiaoshan Hospital, Hangzhou 311200, China

2. Xiaoshan Hospital of Chinese Traditional Medicine, Hangzhou 311200, China

Received Date: 2013-11-14

Rev Recd Date: 2014-03-31

Key words:

Abstract: Objective To compare the therapeutic effectiveness and safeness of venlafaxine sustained-release capsules and citalopram tablets in the treatment of post-stroke depression. Methods 60 patients were randomly divided into venlafaxine group (n=30)and citalomram group(n=30) for 8 weeks treatment. Hamilton rating scale for depression(HAMD) and treatment emergent system scale (TESS) were used to evaluate the efficacy and side effects, respectively. Results After 4-8 weeks of treatment,both scores of HAMD of the two groups decreased significantly(P<0.05),but there was no difference between the two groups(P>0.05). The total scores of HAMD in venlafaxine group were notably lower than citalopram group after 2 weeks(P<0.05). There was no significant difference in side effects between the two groups(P>0.05). Conclusion There was no significant difference in gross curative effect and side effects between two groups; venlafaxine worked faster compared to citalopram.

HTML

Reference (10)

[1]	芮雪,范晓华,潘卫萍.脑卒中后抑郁发生率及其相关因素的调查分析[J].医学信息,2012,23(6):1939-1940.
[2]	Johnson JL Minaik PA Nystrom KV,et al.Poststroke depression incidence and risk factors: an intergrave literature review[J].J Neurosci Nurs,2006,38(4 Suppl):316-327.
[3]	Jia H,Damush TM,Qin H,et al.The impact of poststroke depression on healthcare use by veterans with acute stroke[J].Stroke,2006,37:2796-2801.
[4]	Begre S,Traber M,Gerber M,et al.Change in pain severity with open label yenlafaxine use in patients with a depressive symptomatology: an observational study in primary care[J].Eur Psychiatr,2008,23(3):178-186.
[5]	金卫东,冯斌.文拉法辛治疗抑郁症的循证医学证据[J].四川精神卫生,2005,18(1):64.
[6]	中华神经科学会,中华神经外科学会.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379.
[7]	世界卫生组织. ICD-10精神与行为障碍分类[M].北京:人民卫生出版社,1993:54.
[8]	周国平,李丹.脑卒中后抑郁的相关因素调查[J].中国误诊学杂志,2009,9(31):7807.
[9]	沈渔邨. 精神病学[M].5版.北京:人民卫生出版社,2009:857.
[10]	彭代辉,黄佳.文拉法辛缓释片与文拉法辛缓释胶囊治疗抑郁症的随机、双盲对照研究[J].中国新药与临床杂志,2013,32(4):322.

Message Board

Comparative study of venlafaxine sustained-release capsules and citalopram tablet in the treatment of post-stroke depression

doi: 10.3969/j.issn.1006-0111.2015.02.022

Abstract

References

Proportional views

通讯作者: 陈斌, [email protected]

Article Metrics

Related

Proportional views