Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 33 Issue 2
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(2): 171-172

LÜ Jianfeng, LIU Hua, YE Aiqin, LIU Jun, DING Rongjie. Observation of glutathione to prevent oxaliplatin-induced hepatic lesion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021
Citation: LÜ Jianfeng, LIU Hua, YE Aiqin, LIU Jun, DING Rongjie. Observation of glutathione to prevent oxaliplatin-induced hepatic lesion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021
shu

Observation of glutathione to prevent oxaliplatin-induced hepatic lesion

doi: 10.3969/j.issn.1006-0111.2015.02.021

  • Taixing People's Hospital, Taixing 225400, China

  • Received Date: 2013-12-10
  • Rev Recd Date: 2014-03-17
  • Objective To observe the curative effect of magnesium isoglycyrrhizinate in prevention of liver injury induced by oxaliplatin. Methods The control group used oxaliplatin, leucovorin, 5-fluorouracil chemotherapy, the treatment group were treated with oxaliplatin, leucovorin, 5-fluorouracil chemotherapy and simultaneous magnesium isoglycyrrhizinate were used at the same time. With 28 d for 1 course of treatment, the treatment period consisted of 2-4 courses, observation of patients and the proportion of liver injury were made. Results In the control group, liver injury incidence rate was 44.4%, the rate of injury was 19.4% in treatment group, there was significant difference between the two groups (P<0.01). Conclusion Magnesium isoglycyrrhizinate could be effective in prevention of oxaliplatin induced liver injury.
  • [1] 叶爱琴,吕建峰,刘 华.草酸铂致肝损伤的临床观察[J].肿瘤防治研究,2007,34(10):783-784.
    [2] 孙 燕,周际昌.临床肿瘤内科手册[M].4版.北京:人民卫生出版社,2004:102.
    [3] Slade JH, Alattar ML, Fogelman DR, et al. Portal hypertension associated with oxaliplatin administration: clinical manifestations of hepatic sinusoidal injury[J].Clin Colorectal Cancer,2009,8(4): 225-230.
    [4] Overman MJ, Maru DM, Charnsangavej C, et al. Oxaliplatin-mediated increase in spleen size as a biomarker for the development of hepatic sinusoidal injury[J].J Clin Oncol,2010,28(15): 2549-2555.
    [5] Motoori S, Kawase T, Nishimura H, et al. Two cases of advanced colorectal cancer which demonstrated the reversibility of oxaliplatin-mediated increase in splenic volume[J].Gan To Kagaku Ryoho,2011,38(4): 677-680.
    [6] 陈玉强,洪节约,张雅雅,等.异甘草酸镁治疗肝癌动脉栓塞化疗肝损伤的临床研究[J].实用临床医药杂志,2010,14(17):15-17.
    [7] Mao YM,Zeng MD,Chen Y.Magnesium isoglycyrrhizinate in the treatment of chronic liver diseases:a randomized,doubleblind,multi-doses,active drug controlled,multi-center study[J].Zhonghua Gan Zang Bing Za Zhi,2009,17:847-851.
    [8] 赵艳娟,杨梓梅.异甘草酸镁治疗慢性重型乙型肝炎的临床疗效观察[J].临床肝胆病杂志,2010,26(5):524-526.
    [9] 董大勇.异甘草酸镁治疗慢性乙型肝炎的临床观察.实用临床医药杂志,2010,14(19):36-37.
  • 加载中
通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(3920) PDF downloads(455) Cited by()

Related
Proportional views

Observation of glutathione to prevent oxaliplatin-induced hepatic lesion

doi: 10.3969/j.issn.1006-0111.2015.02.021
  • Taixing People's Hospital, Taixing 225400, China
  • Received Date: 2013-12-10
  • Rev Recd Date: 2014-03-17

Abstract: Objective To observe the curative effect of magnesium isoglycyrrhizinate in prevention of liver injury induced by oxaliplatin. Methods The control group used oxaliplatin, leucovorin, 5-fluorouracil chemotherapy, the treatment group were treated with oxaliplatin, leucovorin, 5-fluorouracil chemotherapy and simultaneous magnesium isoglycyrrhizinate were used at the same time. With 28 d for 1 course of treatment, the treatment period consisted of 2-4 courses, observation of patients and the proportion of liver injury were made. Results In the control group, liver injury incidence rate was 44.4%, the rate of injury was 19.4% in treatment group, there was significant difference between the two groups (P<0.01). Conclusion Magnesium isoglycyrrhizinate could be effective in prevention of oxaliplatin induced liver injury.

LÜ Jianfeng, LIU Hua, YE Aiqin, LIU Jun, DING Rongjie. Observation of glutathione to prevent oxaliplatin-induced hepatic lesion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021
Citation: LÜ Jianfeng, LIU Hua, YE Aiqin, LIU Jun, DING Rongjie. Observation of glutathione to prevent oxaliplatin-induced hepatic lesion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021
shu

    HTML

Reference (9)

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: [email protected]

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return