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Volume 33 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(2): 114-118

WANG Huan, SHE Lan, WANG Linzhao, MA Zhiqiang, ZHANG Xinrong, YANG Feng. Oxidized meosporous carbon nanospheres as carriers for paclitaxel[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 114-118. doi: 10.3969/j.issn.1006-0111.2015.02.005
Citation: WANG Huan, SHE Lan, WANG Linzhao, MA Zhiqiang, ZHANG Xinrong, YANG Feng. Oxidized meosporous carbon nanospheres as carriers for paclitaxel[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 114-118. doi: 10.3969/j.issn.1006-0111.2015.02.005
shu

Oxidized meosporous carbon nanospheres as carriers for paclitaxel

doi: 10.3969/j.issn.1006-0111.2015.02.005
  • 1.

    School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China

  • 2.

    Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 3.

    School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2014-09-18
  • Rev Recd Date: 2015-01-10
  • Objective To prepare oxidized mesoporous carbon nanospheres and investigate potential application as drug delivery carriers for paclitaxel. Methods Physicochemical properties such as morphology, diameter, pore diameter and pore volume were characterized. Drug-loading capacity was measured and drug release behavior in vitro was investigated by dialysis method. In vitro antitumour effect was evaluated by CCK-8 methods. Results The synthesized oxidized mesoporous carbon nanospheres had an average diameter of 140 nm, Zeta potential of -36 mV, high specific surface area of 704.63 m2/g,high drug-loading capacity of 45.6%. Conclusion Oxidized mesoporous carbon nanospheres have promising application in anti-cancer drug delivery system.
  • [1] Yuan X, Xing W, Zhuo SP, et al. Adsorption of bulky molecules of nonylphenol ethoxylate on ordered mesoporous carbons[J]. J Colloid Interfac Sci, 2008, 322(2): 558-565.
    [2] Peng H, Ma GF, Sun KJ, et al. Formation of carbon nanosheets via simultaneous activation and catalytic carbonization of macroporous anion-exchange resin for supercapacitors application[J]. ACS Appl Mater Interfac, 2014, 6(23):20795-20803.
    [3] Li FH. Layer-by-layer loading iron onto mesoporous silica surfaces: synthesis, characterization and application for As(V) removal[J]. Microporous Mesoporous Mater, 2013, 171: 139 146.
    [4] Vallet RM, Ramila A, Real RP. A new property of MCN-41: drug delivery system[J]. Chem Mater, 2001,13: 308-311.
    [5] Chen B, Quan GL, Wang ZH, et al. Hollow mesoporous silicas as a drug solution delivery system for insoluble drugs[J]. Powder Technol, 2013, 240: 48 53.
    [6] Shen S, Tang H, Zhang X, et al. Targeting mesoporous silica-encapsulated gold nanorods for chemo-photothermal therapy with near-infrared radiation[J]. Biomaterials, 2013, 34(12): 3150-3158.
    [7] Zhao P, Jiang H, Jiang T, et al. Inclusion of celecoxib into fibrous ordered mesoporous carbon for enhanced oral bioavailability and reduced gastric irritancy[J]. Eur J Pharm Sci, 2012, 45(5): 639-647.
    [8] Wang X, Liu P, Tian Y. Ordered mesoporous carbons for ibuprofen drug loading and release behavior[J]. Microporous Mesoporous Mater, 2011, 142(1): 334-340.
    [9] Fang Y, Gu D, Zou Y, et al. A low-concentration hydrothermal synthesis of biocompatible ordered mesoporous carbon nanospheres with tunable and uniform size[J]. Angew Chem Int Ed Engl, 2010, 49(43): 7987-7991.
    [10] Li Y, Zhong J, Yang X, et al. Simple synthesis of semi-graphitized ordered mesoporous carbons with tunable pore sizes[J]. New Carbon Mater, 2011, 26(2): 123-129.
    [11] Wang C, Xu H, Liang C, et al. Iron oxide @ polypyrrole nanoparticles as a multifunctional drug carrier for remotely controlled cancer therapy with synergistic antitumor effect[J]. ACS Nano, 2013, 7(8): 6782-6795.
    [12] Gu JL,Su SS,Li YS,et al.Hydrophilic mesoporous carbon nanoparticles as carriers for sustained release of hydrophobic anti-cancer drugs[J].Chem Commun,2011,47(7):2101-2103.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Oxidized meosporous carbon nanospheres as carriers for paclitaxel

doi: 10.3969/j.issn.1006-0111.2015.02.005
  • 1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China
  • 2. Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 3. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2014-09-18
  • Rev Recd Date: 2015-01-10

Abstract: Objective To prepare oxidized mesoporous carbon nanospheres and investigate potential application as drug delivery carriers for paclitaxel. Methods Physicochemical properties such as morphology, diameter, pore diameter and pore volume were characterized. Drug-loading capacity was measured and drug release behavior in vitro was investigated by dialysis method. In vitro antitumour effect was evaluated by CCK-8 methods. Results The synthesized oxidized mesoporous carbon nanospheres had an average diameter of 140 nm, Zeta potential of -36 mV, high specific surface area of 704.63 m2/g,high drug-loading capacity of 45.6%. Conclusion Oxidized mesoporous carbon nanospheres have promising application in anti-cancer drug delivery system.

WANG Huan, SHE Lan, WANG Linzhao, MA Zhiqiang, ZHANG Xinrong, YANG Feng. Oxidized meosporous carbon nanospheres as carriers for paclitaxel[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 114-118. doi: 10.3969/j.issn.1006-0111.2015.02.005
Citation: WANG Huan, SHE Lan, WANG Linzhao, MA Zhiqiang, ZHANG Xinrong, YANG Feng. Oxidized meosporous carbon nanospheres as carriers for paclitaxel[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 114-118. doi: 10.3969/j.issn.1006-0111.2015.02.005
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