Preparation and characterization of chrysin-hydroxypropyl-β-cyclodextrins inclusion compound

ZENG Qian; JI Hui; TANG Huihui; XIE Xueyuan

doi:10.3969/j.issn.1006-0111.2014.06.014

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Objective To prepare the water soluble chrysin-hydroxypropyl-β-cyclodextrins inclusion compound and widen the administration path of chrysin. Methods The cogrinding method had been used to prepare chrysin-hydroxypropyl-β-cyclodextrins inclusion compound. The PXRD, DSC and IR techniques had been used to characterize the inclusion compound. Results Chrysin and hydroxypropyl-β-cyclodextrins had formed the inclusion compound, and the formation of the inclusion compound could increase solubility by 120.7 times. Conclusion The inclusion compound preparation method was simple and available, which was suitable to improve the bioavailability.

Preparation and characterization of chrysin-hydroxypropyl-β-cyclodextrins inclusion compound

1. Department of Pharmacy, Navy General Hospital, Beijing 100048, China

2. The Chinese Navy Healthcare Committee Office, Beijing 100841, China

Received Date: 2014-04-08

Rev Recd Date: 2014-09-09

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Abstract: Objective To prepare the water soluble chrysin-hydroxypropyl-β-cyclodextrins inclusion compound and widen the administration path of chrysin. Methods The cogrinding method had been used to prepare chrysin-hydroxypropyl-β-cyclodextrins inclusion compound. The PXRD, DSC and IR techniques had been used to characterize the inclusion compound. Results Chrysin and hydroxypropyl-β-cyclodextrins had formed the inclusion compound, and the formation of the inclusion compound could increase solubility by 120.7 times. Conclusion The inclusion compound preparation method was simple and available, which was suitable to improve the bioavailability.

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Preparation and characterization of chrysin-hydroxypropyl-β-cyclodextrins inclusion compound

doi: 10.3969/j.issn.1006-0111.2014.06.014

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通讯作者: 陈斌, [email protected]

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