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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2014  >  32(6): 409-411,459

ZHANG Xiuli, MA Yueqin, LI Gang. Research development of lipid microsphere delivery system[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 409-411,459. doi: 10.3969/j.issn.1006-0111.2014.06.003
Citation: ZHANG Xiuli, MA Yueqin, LI Gang. Research development of lipid microsphere delivery system[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 409-411,459. doi: 10.3969/j.issn.1006-0111.2014.06.003
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Research development of lipid microsphere delivery system

doi: 10.3969/j.issn.1006-0111.2014.06.003

  • Department of Pharmacy, No. 94 Hospital of PLA, Nanchang 330002, China

  • Received Date: 2013-05-21
  • Rev Recd Date: 2014-03-17
  • Lipid microsphere drug delivery system is a hot issue in pharmceutics studies. In this paper, the mechanism, preparation method and the key influence factors of lipid microsphere drug delivery system were reviewed respectively. Some new discovery and development were introduced in order to enhance the development and application of lipid microsphere drug delivery system as a drug delivery tool.
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    [4] Morais JM, Burgess DJ. Long acting injections and implants: micro-and nano-emulsions (controlled release parenteral drug delivery systems)[M].London: Springer, 2012: 221-238.
    [5] Yue PF, Lu XY, Liao MX, et al. The effect of oil components and homogenization conditions on the physicochemical properties of zedoary turmeric oil submicron emulsions[J]. J Dispers Sci Technol, 2010, 31(11):1535-1540.
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    [10] Yue PF, Li FQ, Liao MX, et al. Process optimization, characterization, and release study in vitro of an intravenous puerarin lipid micropheres loaded with the phospholipid complex[J]. J Dispers Sci Technol, 2011, 32(1): 1-10.
    [11] Yue PF, Zheng Q, Wu B, et al. Application of plackett-burman design and box-behnken design to achieve process optimization for geniposide submicron emulsion[J]. J Dispers Sci Technol, 2012, 33(2): 213-222.
    [12] Ma YQ, Li G, Xu JH, et al. Combination of submicroemulsion and phospholipid complex for novel delivery of ursodeoxycholic acid[J]. Pharm Dev Technol,2014,19(3):363-372.
    [13] Gulati Neha, Gupta Himanshu. Parenteral drug delivery: a review[J]. Recent Patent Drug Deliv Form, 2011, 5(2): 133-145.
    [14] Yamamura K, Nakao M, Yano K, et al. Stability of forskolin in lipid emulsions and oil/water partition coefficients[J]. Chem Pharm Bull,1991, 39(4):1032-1034.
    [15] Bhalerao AV, Singh SS. In situ gelling ophthalmic drug delivery system for glaucoma[J]. Int J Pharm Biosci, 2011, 2(2): 7-14.
    [16] Patel Y, Poddar A, Sawant K. Formulation and characterization of Cefuroxime Axetil nanoemulsion for improved bioavailability[J]. J Pharm Bioallied Sci, 2012, 4(1): S4-S5.
    [17] Ammar H, Salama H, Ghorab M, et al. Nanoemulsion as a potential ophthalmic drug delivery system for Dorzolamide hydrochloride[J]. AAPS Pharm Sci Tech, 2009, 10(3): 808-819.
    [18] Gan L, Wang J, Jiang M, et al.Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers[J]. Drug Discov Today, 2013, 18(5-6): 290-297.
    [19] Lu Y, Qi J, Wu W. Absorption, disposition and pharmacokinetics of nanoemulsions[J]. Curr Drug Metab,2012, 13(4): 418-428.
    [20] Sultana Y, Maurya DP, Iqbal Z,et al. Nanotechnology in ocular delivery: current and future directions[J]. Drugs Today, 2011, 47(6): 441-455.
    [21] Zhang N, Zhang Q, Chu T, et al. Formulation optimization of prostaglandin E1-loaded lipid emulsion: enhanced stability and reduced biodegradation[J]. Pharm Dev Tech, 2013, 18(4): 804-812.
    [22] GaoY, Xu PF, Chen LL, Li YP. Prostaglandin E1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect[J]. Int J Pharm, 2010, 387(1-2): 263-271.
    [23] Ueki R, Tanimoto M, Tatara T, et al. Emulsion of flurbiprofen axetil reduces propofol injection pain due to a decrease in free propofol concentration[J]. J Anesth, 2007, 21 (3): 325-329.
    [24] Shen J, Gan L, Zhu C, et al. Novel NSAIDs ophthalmic formulation: flurbiprofen axetil emulsion with low irritancy and improved anti-inflammation effect[J]. Int J Pharm, 2011, 412(1-2):115-122.
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Research development of lipid microsphere delivery system

doi: 10.3969/j.issn.1006-0111.2014.06.003
  • Department of Pharmacy, No. 94 Hospital of PLA, Nanchang 330002, China
  • Received Date: 2013-05-21
  • Rev Recd Date: 2014-03-17

Abstract: Lipid microsphere drug delivery system is a hot issue in pharmceutics studies. In this paper, the mechanism, preparation method and the key influence factors of lipid microsphere drug delivery system were reviewed respectively. Some new discovery and development were introduced in order to enhance the development and application of lipid microsphere drug delivery system as a drug delivery tool.

ZHANG Xiuli, MA Yueqin, LI Gang. Research development of lipid microsphere delivery system[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 409-411,459. doi: 10.3969/j.issn.1006-0111.2014.06.003
Citation: ZHANG Xiuli, MA Yueqin, LI Gang. Research development of lipid microsphere delivery system[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 409-411,459. doi: 10.3969/j.issn.1006-0111.2014.06.003
shu

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