Inhibitory activity of α-glucosidase in four starfishes

ZHANG Gaiyun; FAN Lin; HOU Zhonghai; ZHANG Yubian; YANG Yanliu

doi:10.3969/j.issn.1006-0111.2014.04.012

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Objective To search for starfishes with hopoglycemic activity and orientate the bioactive fractions. Methods Firstly, the crude extracts of four starfishes were subjected to oral glucose tolerance test on normal and diabetic mice.And then the in vitro α-glucosidase activity assay was introduced to confirm the bioactive fractions. Results The crude extract of Asterias rollestoni could lower the blood glucose of normal and diabetic mice after 0.5 h and 1 h.Furthermore, its n-BuOH fraction exhibited potent α-glucosidase inhibitoary activity. Conclusion The n-BuOH extract of Asterias rollestoni had a potent α-glucosidase inhibitoary activity.

Inhibitory activity of α-glucosidase in four starfishes

1. Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China

2. School of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China

Received Date: 2013-05-22

Rev Recd Date: 2013-09-14

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Abstract: Objective To search for starfishes with hopoglycemic activity and orientate the bioactive fractions. Methods Firstly, the crude extracts of four starfishes were subjected to oral glucose tolerance test on normal and diabetic mice.And then the in vitro α-glucosidase activity assay was introduced to confirm the bioactive fractions. Results The crude extract of Asterias rollestoni could lower the blood glucose of normal and diabetic mice after 0.5 h and 1 h.Furthermore, its n-BuOH fraction exhibited potent α-glucosidase inhibitoary activity. Conclusion The n-BuOH extract of Asterias rollestoni had a potent α-glucosidase inhibitoary activity.

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Inhibitory activity of α-glucosidase in four starfishes

doi: 10.3969/j.issn.1006-0111.2014.04.012

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通讯作者: 陈斌, [email protected]

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