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Volume 32 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2014  >  32(4): 273-277

QIU Jun, XU Yanru, ZENG Qiping, ZHONG Guixiang, ZHU Jianming, SONG Hongtao. Preparation and detection of in vitro dissolution of finasteride coated dispersible tablets[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 273-277. doi: 10.3969/j.issn.1006-0111.2014.04.009
Citation: QIU Jun, XU Yanru, ZENG Qiping, ZHONG Guixiang, ZHU Jianming, SONG Hongtao. Preparation and detection of in vitro dissolution of finasteride coated dispersible tablets[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 273-277. doi: 10.3969/j.issn.1006-0111.2014.04.009
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Preparation and detection of in vitro dissolution of finasteride coated dispersible tablets

doi: 10.3969/j.issn.1006-0111.2014.04.009
  • 1.

    Department of Pharmacy, Gulangyu island Sanatorium of Nanjing Military Region, Xiamen, 361002, China

  • 2.

    Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China

  • Received Date: 2013-08-13
  • Rev Recd Date: 2013-12-06
  • Objective To optimize the prescription and preparation technology of finasteride dispersible tablets. Methods Wet granulation technique was applied to optimize the formulation and technology of finasteride tablets. Results The formulation of finasteride tablets was that microcrystalline cellulose and lactose acts as diluent, 5% of low-substituted hydroxypropyl cellulose acts as disintegrant, 5% of povidone in alcohol water mixture acts as adhesive and 15% of opadry 85 G type acts as coating solution.The percentage of dissolution was more than 90% in 45 miniutes. Conclusion The self-made finasteride tablets had stable quality, reliable process and were suitable for industrialized mass production.
  • [1] 刘建芳, 邓 鸣, 侯艳宁. 非那雄胺的药理及临床应用研究进展[J]. 华北国防医药, 2006, 18(4):286.
    [2] 胡容峰, 冯志英, 王 剑, 等. 非那雄胺的研制及稳定性[J]. 中国医院药学杂志, 2001,22(5):287-289.
    [3] 冯泽岸, 廖明琪, 邵婷玑, 等. 南沙参多糖分散片的制备[J]. 中国医院药学杂志,2012,33(9):699-703.
    [4] 国家药典委员会. 中华人民共和国药典2010版二部[S]. 北京:化学工业出版社,2010:33.
    [5] 崔福德. 药剂学[M]. 北京:人民卫生出版社,2007:335-339.
    [6] 韩 莎, 朱云峰, 曹青日, 等. 三七总皂苷分散片的制备及体外评价[J]. 中成药, 2010,32(8):1324-1328.
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Preparation and detection of in vitro dissolution of finasteride coated dispersible tablets

doi: 10.3969/j.issn.1006-0111.2014.04.009
  • 1. Department of Pharmacy, Gulangyu island Sanatorium of Nanjing Military Region, Xiamen, 361002, China
  • 2. Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China
  • Received Date: 2013-08-13
  • Rev Recd Date: 2013-12-06

Abstract: Objective To optimize the prescription and preparation technology of finasteride dispersible tablets. Methods Wet granulation technique was applied to optimize the formulation and technology of finasteride tablets. Results The formulation of finasteride tablets was that microcrystalline cellulose and lactose acts as diluent, 5% of low-substituted hydroxypropyl cellulose acts as disintegrant, 5% of povidone in alcohol water mixture acts as adhesive and 15% of opadry 85 G type acts as coating solution.The percentage of dissolution was more than 90% in 45 miniutes. Conclusion The self-made finasteride tablets had stable quality, reliable process and were suitable for industrialized mass production.

QIU Jun, XU Yanru, ZENG Qiping, ZHONG Guixiang, ZHU Jianming, SONG Hongtao. Preparation and detection of in vitro dissolution of finasteride coated dispersible tablets[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 273-277. doi: 10.3969/j.issn.1006-0111.2014.04.009
Citation: QIU Jun, XU Yanru, ZENG Qiping, ZHONG Guixiang, ZHU Jianming, SONG Hongtao. Preparation and detection of in vitro dissolution of finasteride coated dispersible tablets[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 273-277. doi: 10.3969/j.issn.1006-0111.2014.04.009
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