Preclinical pharmacodynamic research of Juhuang Qingre San

MI Li; CHEN Wansheng; LI Jingchao; WU Guangtong

doi:10.3969/j.issn.1006-0111.2014.03.013

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Objective To investigate the efficacy on antibacterial, antipyretic, analgesic, anti-inflammatory and immune regulation of Juhuang Qingre San. Methods Efficacy on antibacterial was evaluated by the method of doubling dilution,vivo antibacterial effect was observed by inoculating BABL/C mice with Streptococcus pneumonia,efficacy on antipyretic was investigated by using endotoxin fever model,analgesic function was assessed using mice hot plate and torsion analgesic method,effect of anti inflammatory was assessed with rat paw edema model and mice Peritoneal capillary permeability model, the role of regulating immune system was evaluated by mice carbon clearance test. Results Juhuang Qingre San can decrease the death rate of mice in antibacterial test in vitro or vivo,in low and mid dose group of Juhuang Qingre San, heating temperature of rabbits decreased significantly 2-3 h after administration (P<0.05), and high dosage group decreased significantly 2-4 h after administration (P<0.05),the mice pain threshold increased significantly (P<0.05) after the administration of 1.5, 2, 3 h in every group of Juhuang Qingre San was, and can significantly reduce the number of mice writhing after intraperitoneal injection (P<0.05),rat paw swelling rate decreased significantly 1, 2, 3, 4, 5 h after administration in each dosage group of Juhuang Qingre San (P<0.05), peritoneal capillary permeability decreased in the acute inflammation model of mice (P<0.05), in carbon particle clearance test of immune regulation, K value of high and medium dose group of Juhuang Qingre San was increased, while the value of alpha increased as well(P<0.05). Conclusion The results suggested that Juhuang Qingre San has efficacy of antibacterial, antipyretic, analgesic, anti-inflammatory and immune enhancing.

Preclinical pharmacodynamic research of Juhuang Qingre San

1. Department of Pharmacy, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai 200003, China

2. Department of Pharmacy, Shanghai General Hospital of Army Police, Shanghai 201103, China

Received Date: 2014-02-27

Rev Recd Date: 2014-04-17

Key words:

Abstract: Objective To investigate the efficacy on antibacterial, antipyretic, analgesic, anti-inflammatory and immune regulation of Juhuang Qingre San. Methods Efficacy on antibacterial was evaluated by the method of doubling dilution,vivo antibacterial effect was observed by inoculating BABL/C mice with Streptococcus pneumonia,efficacy on antipyretic was investigated by using endotoxin fever model,analgesic function was assessed using mice hot plate and torsion analgesic method,effect of anti inflammatory was assessed with rat paw edema model and mice Peritoneal capillary permeability model, the role of regulating immune system was evaluated by mice carbon clearance test. Results Juhuang Qingre San can decrease the death rate of mice in antibacterial test in vitro or vivo,in low and mid dose group of Juhuang Qingre San, heating temperature of rabbits decreased significantly 2-3 h after administration (P<0.05), and high dosage group decreased significantly 2-4 h after administration (P<0.05),the mice pain threshold increased significantly (P<0.05) after the administration of 1.5, 2, 3 h in every group of Juhuang Qingre San was, and can significantly reduce the number of mice writhing after intraperitoneal injection (P<0.05),rat paw swelling rate decreased significantly 1, 2, 3, 4, 5 h after administration in each dosage group of Juhuang Qingre San (P<0.05), peritoneal capillary permeability decreased in the acute inflammation model of mice (P<0.05), in carbon particle clearance test of immune regulation, K value of high and medium dose group of Juhuang Qingre San was increased, while the value of alpha increased as well(P<0.05). Conclusion The results suggested that Juhuang Qingre San has efficacy of antibacterial, antipyretic, analgesic, anti-inflammatory and immune enhancing.

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Reference (11)

[1]	王杰,魏超,吕曙华. HPLC法测定芎菊上清丸中绿原酸[J]. 中草药,2006,37(7):1032-1033.
[2]	牛俐,郑红梅,赵英. 芎菊上清丸配合心理疏导治疗偏头痛52例[J]. 中医药临床杂志,2005,17(1):40.
[3]	杨爱霞,阮金兰,王晓仙,等. 退热解毒灵颗粒的解热抗炎作用[J]. 中国医院药学杂志,2012,32(3):170-172.
[4]	武月萍,张建刚. 中药灌肠剂治疗小儿外感发热215 例临床观察[J]. 现代预防医学,2012,39(14):3520-3522.
[5]	张风清,吴碧珍,王牡丹. 风寒感冒和风热感冒的鉴别与治疗[J]. 内蒙古中医药,2012,31(8): 16.
[6]	陈艳,蔡小军. 病症结合药理模型的研究思路[J]. 实用药物与临床,2012,5(8): 516-518.
[7]	Fu Y, Chen J, Li Y, et al. Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice[J]. Food Chem,2013, 141(2):1063-1071.
[8]	Siracusa L, Saija A, Cristani M, et al. Phytocomplexes from liquorice (Glycyrrhiza glabra L.) leaves-chemical characterization and evaluation of their antioxidant, anti-genotoxic and anti-inflammatory activity[J]. Fitoterapia,2011,82(4):546-556.
[9]	Cho H, Lim S, Lee Y, et al. Hexane/ethanol extract of Glycyrrhiza uralensis licorice exerts potent anti-inflammatory effects in murine macrophages and in mouse skin[J]. Food Chem,2010, 121(4):959-966.
[10]	马洪第,卢芳汀,陶艳艳,等. 中药免疫调节作用的研究进展[J]. 临床肝胆病杂志,2011,27(5):462-466.
[11]	仇微红,郭世宁,李志华,等. 中药免疫调节作用的研究进展[J]. 广东畜牧兽医科技,2008,33(2): 9-13.

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Preclinical pharmacodynamic research of Juhuang Qingre San

doi: 10.3969/j.issn.1006-0111.2014.03.013

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通讯作者: 陈斌, [email protected]

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