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Volume 32 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2014  >  32(3): 206-208,230

QIN Jianhong. Detection of glinides adulterated in traditional Chinese medicine for diabetes by TLC-SERS[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 206-208,230. doi: 10.3969/j.issn.1006-0111.2014.03.011
Citation: QIN Jianhong. Detection of glinides adulterated in traditional Chinese medicine for diabetes by TLC-SERS[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 206-208,230. doi: 10.3969/j.issn.1006-0111.2014.03.011
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Detection of glinides adulterated in traditional Chinese medicine for diabetes by TLC-SERS

doi: 10.3969/j.issn.1006-0111.2014.03.011

  • Department of Pharmacy, No. 169 Hospital of PLA, Hengyang 421001, China

  • Received Date: 2014-04-02
  • Rev Recd Date: 2014-04-21
  • Objective To establish detection method of glinides adulterated illegally in hypoglycemic traditional Chinese medicine (TCM) by surface enhanced Raman spectroscopy (SERS). Methods Adulterated chemicals and TCM matrixes were separated by TLC first. Then trace substances in TLC plate was tested by SERS method. By investigating SERS detection conditions of glinides chemicals in simulated positive samples, a detection method was established to detect illegal adulterant in hypoglycemic TCM. Results Better SERS spectra of glinides could be obtained by silver sol prepared with organic solvent DMF. Conclusion The detection method coupled with TLC and SERS in this paper was simple, fast and economical which could be used to detect glinides adulterated illegally in hypoglycemic Chinese patent medicine quickly.
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    [2] 陈玉武,张夙萍,高晓昱.薄层色谱法初筛少数中药制剂中添加降糖类化学药物[J]. 药物分析杂志,2010,30(7): 1298-1300.
    [3] 吕情花,李永华. HPLC法测定中成药通宣理肺胶囊(颗粒、片)中非法添加的化学药品[J]. 中国现代药物应用, 2013, 7(21): 225-226.
    [4] 钟伟新,王 平,曾 凡.HPLC法测定中成药和保健食品中违法添加的6种肾上腺皮质激素[J]. 今日药学,2012,22(5): 282-284.
    [5] 李 丹,文红梅,崔福春,等. LC-MS/MS法快速测定中成药、保健食品中非法添加的36种化学成分[J]. 药物分析杂志, 2010, 30(8): 1527-1532.
    [6] Chen Y,Zhao L,Lu F,et al. Determination of synthetic drugs used to adulterate botanical dietary supplements using QTRAP LC-MS/MS[J]. Food Addit Contam Part A, 2009, 26(5): 595-603.
    [7] 陈 斌,余岳林,张少敏,等.中成药和保健食品中非法添加西药成分检测方法的探索[J]. 药物分析杂志,2009, 29(10): 1677-1680.
    [8] 颜 杰,刘志强,程振田.中成药及中药保健食品中非法添加化学药品现状与对策[J]. 中国医疗前沿, 2007, 42(9):716-718.
    [9] Li D,Qu LL,Zhai WL,et al. Facile on-site detection of substituted aromatic pollutants in water using thin layer chromatography combined with surface-enhanced Raman spectroscopy[J]. Environ Sci Technol,2011, 45(9): 4046-4052.
    [10] Zhu QX,Cao YB,Chai YY,et al. Rapid on-site TLC-SERS detection of four antidiabetes drugs used as adulterants in botanical dietary supplements[J]. Anal Bioanal Chem, 2014, 406:1877.
    [11] Huang RF,Han S,Li XS.Detection of tobacco-related biomarkers in urine samples by surface-enhanced Raman spectroscopy coupled with thin-layer chromatography[J]. Anal Bioanal Chem,2013, 405(21):6815.
    [12] Federica P,Nobuko SB,Marco L,et al. TLC-SERS study of Syrian rue (Peganum harmala) and its main alkaloid constituents[J]. J Raman Spectrosc, 2013, 44(1): 102.
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Detection of glinides adulterated in traditional Chinese medicine for diabetes by TLC-SERS

doi: 10.3969/j.issn.1006-0111.2014.03.011
  • Department of Pharmacy, No. 169 Hospital of PLA, Hengyang 421001, China
  • Received Date: 2014-04-02
  • Rev Recd Date: 2014-04-21

Abstract: Objective To establish detection method of glinides adulterated illegally in hypoglycemic traditional Chinese medicine (TCM) by surface enhanced Raman spectroscopy (SERS). Methods Adulterated chemicals and TCM matrixes were separated by TLC first. Then trace substances in TLC plate was tested by SERS method. By investigating SERS detection conditions of glinides chemicals in simulated positive samples, a detection method was established to detect illegal adulterant in hypoglycemic TCM. Results Better SERS spectra of glinides could be obtained by silver sol prepared with organic solvent DMF. Conclusion The detection method coupled with TLC and SERS in this paper was simple, fast and economical which could be used to detect glinides adulterated illegally in hypoglycemic Chinese patent medicine quickly.

QIN Jianhong. Detection of glinides adulterated in traditional Chinese medicine for diabetes by TLC-SERS[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 206-208,230. doi: 10.3969/j.issn.1006-0111.2014.03.011
Citation: QIN Jianhong. Detection of glinides adulterated in traditional Chinese medicine for diabetes by TLC-SERS[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 206-208,230. doi: 10.3969/j.issn.1006-0111.2014.03.011
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