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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2014  >  32(3): 203-205

XU Nongzhang, JIN Zhonghua, WANG Zhijing. Study on drug resistance of Acinetobacter baumannii before and after special anti-bacterial drugs remediation[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 203-205. doi: 10.3969/j.issn.1006-0111.2014.03.010
Citation: XU Nongzhang, JIN Zhonghua, WANG Zhijing. Study on drug resistance of Acinetobacter baumannii before and after special anti-bacterial drugs remediation[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 203-205. doi: 10.3969/j.issn.1006-0111.2014.03.010
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Study on drug resistance of Acinetobacter baumannii before and after special anti-bacterial drugs remediation

doi: 10.3969/j.issn.1006-0111.2014.03.010

  • Department of Pharmacy, Zhoupu Hospital, Shanghai 201318, China

  • Received Date: 2013-03-13
  • Rev Recd Date: 2013-11-11
  • Objective To investigate the drug resistance of Acinetobacter baumannii and antibiotics use density of all kinds of antibacterial drugs before and after special antibacterial drugs remediation, provide evidence for the follow-up intervention strategies. Methods The experimental results of detected 562 cases Acinetobacter baumannii and sensitivity test were analyzed in our hospital in 2011-2012, combined with using of every type of antibacterial drugs on different time period. Results The number of bacteria detected half year had no significant difference during 2011-2012. The antibiotics use density of beta-lactam、fluroquinoloncs and aminoglycosides declined 22.22(31.92%)、4.19(46.29%)、5.24(68.83%) respectively by special antibacterial drugs remediation. Beta-lactam resistance rates declined significantly to 25%~30%, fluroquinoloncs and aminoglycosides resistance rates also declined, from 50% of the critical point to 20%~30% in the second half of 2012. Conclusion Standardization of antibiotics use density of various antibacterial drugs could help reduce bacterial resistance.
  • [1] 张世阳,连羡玉,金旭红,等.Cox-Staurt趋势检验分析医院感染鲍曼不动杆菌耐药趋势[J].中国全科医学,2012,15(4):450-453.
    [2] 李可强,张振秋,董 平.SPSS统计软件在药学研究中的应用——相关分析与回归分析[J].中医药学刊,2006,24(7):1300-1301.
    [3] 中华人民共和国卫生部.抗菌药物临床应用管理办法[Z].2012-08-01.
    [4] Segal H, Nelson EC,Elisha BG. Genetic environment and transcription of AmpC in an Acinetobacter baumannii clinical isolate. Antimicrob Agents Chemother, 2004, 48(2): 612-614.
    [5] 显 劲,袁汉尧,戴湘春,等.98例鲍曼不动杆菌的β-内酰胺酶的检测及耐药分析[J].中国热带医学, 2007, 7(3): 405-406.
    [6] Devaud M, Kayser FH, Bachi B. Transposon-mediated multiple antibiotic-resistance in acinetobacter strains[J].Antimicrob Agents Chemother,1982, 22 (2): 323-329.
    [7] Shen LL, Mitscher LA, Sharma PN, et al. Mechanism of inhibiiton of DNA gyrase by quinolone antibacterials: a cooperative drug DNA binding model[J].Biochemistry,1989, 28 (9): 3886-3894.
    [8] 糜祖煌,秦 玲.多药耐药鲍氏不动杆菌5类抗菌药物机制研究[J].中华医院感染学杂志, 2008, 18(7): 761-764.
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Study on drug resistance of Acinetobacter baumannii before and after special anti-bacterial drugs remediation

doi: 10.3969/j.issn.1006-0111.2014.03.010
  • Department of Pharmacy, Zhoupu Hospital, Shanghai 201318, China
  • Received Date: 2013-03-13
  • Rev Recd Date: 2013-11-11

Abstract: Objective To investigate the drug resistance of Acinetobacter baumannii and antibiotics use density of all kinds of antibacterial drugs before and after special antibacterial drugs remediation, provide evidence for the follow-up intervention strategies. Methods The experimental results of detected 562 cases Acinetobacter baumannii and sensitivity test were analyzed in our hospital in 2011-2012, combined with using of every type of antibacterial drugs on different time period. Results The number of bacteria detected half year had no significant difference during 2011-2012. The antibiotics use density of beta-lactam、fluroquinoloncs and aminoglycosides declined 22.22(31.92%)、4.19(46.29%)、5.24(68.83%) respectively by special antibacterial drugs remediation. Beta-lactam resistance rates declined significantly to 25%~30%, fluroquinoloncs and aminoglycosides resistance rates also declined, from 50% of the critical point to 20%~30% in the second half of 2012. Conclusion Standardization of antibiotics use density of various antibacterial drugs could help reduce bacterial resistance.

XU Nongzhang, JIN Zhonghua, WANG Zhijing. Study on drug resistance of Acinetobacter baumannii before and after special anti-bacterial drugs remediation[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 203-205. doi: 10.3969/j.issn.1006-0111.2014.03.010
Citation: XU Nongzhang, JIN Zhonghua, WANG Zhijing. Study on drug resistance of Acinetobacter baumannii before and after special anti-bacterial drugs remediation[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 203-205. doi: 10.3969/j.issn.1006-0111.2014.03.010
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