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Volume 32 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2014  >  32(2): 114-117,146

WANG Xiuli, DANG Xiaofang, LIAO Yan, ZHAO Baosheng. Investigation on the influence-factor of preparation of ethyl cellulose ethoce matrix sustained-release tablets for water-soluble drug[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 114-117,146. doi: 10.3969/j.issn.1006-0111.2014.02.010
Citation: WANG Xiuli, DANG Xiaofang, LIAO Yan, ZHAO Baosheng. Investigation on the influence-factor of preparation of ethyl cellulose ethoce matrix sustained-release tablets for water-soluble drug[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 114-117,146. doi: 10.3969/j.issn.1006-0111.2014.02.010
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Investigation on the influence-factor of preparation of ethyl cellulose ethoce matrix sustained-release tablets for water-soluble drug

doi: 10.3969/j.issn.1006-0111.2014.02.010

  • Beijing University of Chinese Medicine, Beijing 100102, China

  • Received Date: 2012-09-06
  • Rev Recd Date: 2013-05-24
  • Objective To systematically investigate the factors of preparation of ethyl cellulose ethoce matrix sustained-release tablets for water-soluble drug. Methods Cordilox was taken as a water-soluble model drug, accumulative release rate was taken as index testing by ultraviolet spectrophotometry,to study the influencing factors through single-factor test, to determine the release degree of ethyl cellulose ethoce matrix sustained-release tablets. Results These preparation parameters such as preparation method, amount, viscosity and grain size and manufacturer of ethyl cellulose ethoce, tablet hardness and specific surface area that were proved to had significantly influence on the accumulative release rate. Conclusion After a series of comprehensive researches, some references could be provided for further study on in vitro release of water-soluble drug from ethyl cellulose ethoce matrix sustained-release tablets.
  • [1] Pather S.I, Russell I, Syce JA, et al. Sustained release theophylline tablets by direct compression part 1:formulation and in vitro testing[J]. Int J Pharm, 1998, 164:1.
    [2] 吕竹芬, 谭载友, 张蜀, 等. 美沙拉嗪缓释片的处方筛选及体外释放度研究[J].中国现代应用药学杂志, 2000, 17(6):461.
    [3] 王晋, 张汝华. 用渗滤理论研究乙基纤维素骨架片的最适压片力范围[J].药学学报, 2000, 35(7):531.
    [4] 王晋, 张汝华, 马晓光, 等. 高速搅拌制粒工艺与片剂抗张强度的关系[J].中国医药工业杂志, 1999, 30(9):391.
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Investigation on the influence-factor of preparation of ethyl cellulose ethoce matrix sustained-release tablets for water-soluble drug

doi: 10.3969/j.issn.1006-0111.2014.02.010
  • Beijing University of Chinese Medicine, Beijing 100102, China
  • Received Date: 2012-09-06
  • Rev Recd Date: 2013-05-24

Abstract: Objective To systematically investigate the factors of preparation of ethyl cellulose ethoce matrix sustained-release tablets for water-soluble drug. Methods Cordilox was taken as a water-soluble model drug, accumulative release rate was taken as index testing by ultraviolet spectrophotometry,to study the influencing factors through single-factor test, to determine the release degree of ethyl cellulose ethoce matrix sustained-release tablets. Results These preparation parameters such as preparation method, amount, viscosity and grain size and manufacturer of ethyl cellulose ethoce, tablet hardness and specific surface area that were proved to had significantly influence on the accumulative release rate. Conclusion After a series of comprehensive researches, some references could be provided for further study on in vitro release of water-soluble drug from ethyl cellulose ethoce matrix sustained-release tablets.

WANG Xiuli, DANG Xiaofang, LIAO Yan, ZHAO Baosheng. Investigation on the influence-factor of preparation of ethyl cellulose ethoce matrix sustained-release tablets for water-soluble drug[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 114-117,146. doi: 10.3969/j.issn.1006-0111.2014.02.010
Citation: WANG Xiuli, DANG Xiaofang, LIAO Yan, ZHAO Baosheng. Investigation on the influence-factor of preparation of ethyl cellulose ethoce matrix sustained-release tablets for water-soluble drug[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 114-117,146. doi: 10.3969/j.issn.1006-0111.2014.02.010
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