Synthesis and anti-platelet aggregative activity of novel 2, 5-dihydrofuran derivatives

ZHONG Hanyu; ZHANG Yikai; ZHANG Jingyi; LI Ke

doi:10.3969/j.issn.1006-0111.2014.02.007

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Objective To study the synthesis and anti-platelet aggregative activity of 2-(4-methoxyphenyl)-4-vinyl-2,5-dihydrofuran-3-carboxylic acid derivatives. Methods 17 target compounds were designed, synthesized and determined via ¹H-NMR spectra and MS. The anti-platelet aggregative activities of the target compounds in vitro were assessed by Born method. Results The results of preliminary pharmacological test showed that all the target compounds had good anti-platelet aggregative activity in vitro and compounds 3, 6 and 10 were the best candidates, which had 22.2, 12.8 and 8.6 times than positive control, respectively. Conclusion 2-(4-methoxyphenyl)-4-vinyl-2,5-dihydrofuran-3-carboxylic acid derivatives had a pharmacological activity of anti-coagulation. The anti-platelet aggregative activities of compounds 3, 6 and 10 could be worth to further research.

Synthesis and anti-platelet aggregative activity of novel 2, 5-dihydrofuran derivatives

1. Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

2. Department of Pharmacy, General Hospital of Shenyang Military Region, Shenyang 110016, China

Received Date: 2012-04-24

Rev Recd Date: 2013-01-06

Key words:

Abstract: Objective To study the synthesis and anti-platelet aggregative activity of 2-(4-methoxyphenyl)-4-vinyl-2,5-dihydrofuran-3-carboxylic acid derivatives. Methods 17 target compounds were designed, synthesized and determined via ¹H-NMR spectra and MS. The anti-platelet aggregative activities of the target compounds in vitro were assessed by Born method. Results The results of preliminary pharmacological test showed that all the target compounds had good anti-platelet aggregative activity in vitro and compounds 3, 6 and 10 were the best candidates, which had 22.2, 12.8 and 8.6 times than positive control, respectively. Conclusion 2-(4-methoxyphenyl)-4-vinyl-2,5-dihydrofuran-3-carboxylic acid derivatives had a pharmacological activity of anti-coagulation. The anti-platelet aggregative activities of compounds 3, 6 and 10 could be worth to further research.

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Synthesis and anti-platelet aggregative activity of novel 2, 5-dihydrofuran derivatives

doi: 10.3969/j.issn.1006-0111.2014.02.007

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通讯作者: 陈斌, [email protected]

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