Role of apoptosis in radiation-induced tissue damage

YANG Hong; NI Min; ZHAO Xinbin; TAO Xia

doi:10.3969/j.issn.1006-0111.2014.02.005

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Ionizing radiation is able to induce tissue damage, which is related to cell apoptosis, necrosis and inflammation, etc. The signaling pathway underlying radiation-induced apoptosis remains unclear. However, it's well-accepted that several targets were activated in this process, such as poly (ADP-ribose) polymerase, p53, p38, ceramide, free radicals, etc. Based on these targets, the role of apoptosis in radiation-induced tissue damage was elaborated in this review briefly.

Role of apoptosis in radiation-induced tissue damage

Department of Pharmacy, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai 200003, China

Received Date: 2013-03-11

Rev Recd Date: 2013-06-14

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Abstract: Ionizing radiation is able to induce tissue damage, which is related to cell apoptosis, necrosis and inflammation, etc. The signaling pathway underlying radiation-induced apoptosis remains unclear. However, it's well-accepted that several targets were activated in this process, such as poly (ADP-ribose) polymerase, p53, p38, ceramide, free radicals, etc. Based on these targets, the role of apoptosis in radiation-induced tissue damage was elaborated in this review briefly.

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Role of apoptosis in radiation-induced tissue damage

doi: 10.3969/j.issn.1006-0111.2014.02.005

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通讯作者: 陈斌, [email protected]

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