Preparation of proanthocyanidins phospholipids complex

MIAO Zhiru; XU Chaodou; LU Shuai; JIANG Guojun

doi:10.3969/j.issn.1006-0111.2014.01.008

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Objective To prepare proanthocyanidins phospholipids complex, investigate the physicochemical properties and study the formulation. Methods Proanthocyanidins phospholipids complex was prepared and optimized by solvent evaporation method and physicochemical characteristics of the complex were investigated by means of apparent solubility studies. Results The average entrapment efficiencies of phospholipid complex for proanthocyanidins of grasp seed was 97%. Moreover, there was a great improvement of the solubility of proanthocyanidins phospholipid complex both in water and n-octanol. Conclusion The best method to proanthocyanidins phospholipid complex was achieved, and the physicochemical properties were significantly better from those of proanthocyanidins.

Preparation of proanthocyanidins phospholipids complex

1. Department of Pharmacy, the First People's Hospital of Xiaoshan District, Hangzhou 311200, China

2. Institute for Drug and Instrument Control, General Health Department of PLA, Beijing 100071, China

3. Department of Pharmacy, Xiaoshan Hospital of Zhejiang Province, Xiaoshan 311202, China

Received Date: 2013-08-08

Rev Recd Date: 2013-09-29

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Abstract: Objective To prepare proanthocyanidins phospholipids complex, investigate the physicochemical properties and study the formulation. Methods Proanthocyanidins phospholipids complex was prepared and optimized by solvent evaporation method and physicochemical characteristics of the complex were investigated by means of apparent solubility studies. Results The average entrapment efficiencies of phospholipid complex for proanthocyanidins of grasp seed was 97%. Moreover, there was a great improvement of the solubility of proanthocyanidins phospholipid complex both in water and n-octanol. Conclusion The best method to proanthocyanidins phospholipid complex was achieved, and the physicochemical properties were significantly better from those of proanthocyanidins.

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Preparation of proanthocyanidins phospholipids complex

doi: 10.3969/j.issn.1006-0111.2014.01.008

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通讯作者: 陈斌, [email protected]

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