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Volume 31 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(6): 467-469

WANG Guo-ping, ZHANG Zhong-chen, XIA Chen-mei. The clinical observation of Wuzhi Pian in treatment of alcoholic hepatitis[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 467-469. doi: 10.3969/j.issn.1006-0111.2013.06.020
Citation: WANG Guo-ping, ZHANG Zhong-chen, XIA Chen-mei. The clinical observation of Wuzhi Pian in treatment of alcoholic hepatitis[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 467-469. doi: 10.3969/j.issn.1006-0111.2013.06.020
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The clinical observation of Wuzhi Pian in treatment of alcoholic hepatitis

doi: 10.3969/j.issn.1006-0111.2013.06.020

  • Department of Gastroenterology, The 1st People Hospital of Wenling, Wenling 317500, China

  • Received Date: 2013-01-07
  • Rev Recd Date: 2013-05-30
  • Objective To explore the efficacy of WuzhiPian in the treatment of alcoholic Hepatitis. Methods 110 patients with alcoholic hepatitis were randomly divided into the observed group(accepted treatment of WuzhiPian) and the control group(accepted treatment of Diammonium glycyrrhizinate enteric-coated capsules). The difference of clinical efficacy and alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), gamma glutamyl transpeptidase (γ-GT) were compared between the two groups. Results The effective rate in the observed group(92.86%) was significantly higher than that in the control group(77.78%)(P<0.05); ② The concentration of ALT, AST, TBIL andγ-GT after treatment were significantly lower than that before the treatment(P<0.01); ③After treatment, the concentration of ALT, AST, TBIL andγ-GT in the observed group were significantly lower than that in the control group(P<0.01). Conclusion WuzhiPian could increase therapeutic effect and improve liver function in alcoholic hepatitis patients.
  • [1] 黄顺玲, 戴水奇, 张雪红, 等.湖南省酒精性肝病流行病学调查概况[J].中国医师杂志, 2005, 7(3):426.
    [2] 中华医学会肝病学分会脂肪肝和酒精性肝病学组. 酒精性肝病诊疗指南(2010年修订版) [J]. 中华肝脏病杂志, 2010,18(1):167.
    [3] 中华人民共和国卫生部.中药新药临床研究指导原则(第1辑)[S]. 1993:57.
    [4] O'Shea RS, Dasarathy S, McCullough AJ, et al. Alcoholic liverdisease[J]. Hepatology, 2010, 51(4):307.
    [5] 应景妮. 五酯片治疗轻度药物性肝损害效果观察[J]. 中国乡村医药, 2012, 19(12):50.
    [6] 肖 刚, 熊富良, 张 良, 等. 高效液相色谱法测定五酯分散片中五味子酯甲含量[J]. 中国医院药学杂志, 2007, 27(10):1485.
    [7] 殷晓轩, 尹常健. 酒肝宁煎剂对酒精性肝损伤大鼠CYP2E1及白介素6、肿瘤坏死因子-α含量的影响[J]. 国际中医中药杂志, 2011, 33(4):305.
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The clinical observation of Wuzhi Pian in treatment of alcoholic hepatitis

doi: 10.3969/j.issn.1006-0111.2013.06.020
  • Department of Gastroenterology, The 1st People Hospital of Wenling, Wenling 317500, China
  • Received Date: 2013-01-07
  • Rev Recd Date: 2013-05-30

Abstract: Objective To explore the efficacy of WuzhiPian in the treatment of alcoholic Hepatitis. Methods 110 patients with alcoholic hepatitis were randomly divided into the observed group(accepted treatment of WuzhiPian) and the control group(accepted treatment of Diammonium glycyrrhizinate enteric-coated capsules). The difference of clinical efficacy and alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), gamma glutamyl transpeptidase (γ-GT) were compared between the two groups. Results The effective rate in the observed group(92.86%) was significantly higher than that in the control group(77.78%)(P<0.05); ② The concentration of ALT, AST, TBIL andγ-GT after treatment were significantly lower than that before the treatment(P<0.01); ③After treatment, the concentration of ALT, AST, TBIL andγ-GT in the observed group were significantly lower than that in the control group(P<0.01). Conclusion WuzhiPian could increase therapeutic effect and improve liver function in alcoholic hepatitis patients.

WANG Guo-ping, ZHANG Zhong-chen, XIA Chen-mei. The clinical observation of Wuzhi Pian in treatment of alcoholic hepatitis[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 467-469. doi: 10.3969/j.issn.1006-0111.2013.06.020
Citation: WANG Guo-ping, ZHANG Zhong-chen, XIA Chen-mei. The clinical observation of Wuzhi Pian in treatment of alcoholic hepatitis[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 467-469. doi: 10.3969/j.issn.1006-0111.2013.06.020
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