The anti-inflammatory and analgesic effects of Tuishao granule

ZHANG Shu-yu; YAN Liang-guo; YU Yan-li

doi:10.3969/j.issn.1006-0111.2013.06.019

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Objective To study the anti-inflammatory and analgesic effects of Tuishao granule, and provide the basis for clinical studies of the drug. Methods The analgesic effects of Tuishao granule were evaluated by the writhing reaction of mice induced by glacial acetic acid and hot plate, while the anti-inflammatory effects were analyzed by using the mouse's ear swelling with xylene and the rats paw swelling with egg white.Result Compared with the model group and the control group, latent time was lengthened significantly and the pain threshold was increased, the frequency of writhing was reduced in mice by Tuishao granule, which showed that the paw swelling percentage of rats and ear swelling of mice were inhibited by Tuishao granule. Conclusion Tuishao granule had significant effects on anti-inflammatory and analgesic, which indicatedthat it had favorable effect on the treatment of inflammation and analgesic by anemopyretic cold.

The anti-inflammatory and analgesic effects of Tuishao granule

1. Department of Pharmacy, General Hospital of Jinan Military Command, Jinan 250031, China

2. Jinan University, Jinan 250022, China

Received Date: 2012-11-12

Rev Recd Date: 2013-04-08

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Abstract: Objective To study the anti-inflammatory and analgesic effects of Tuishao granule, and provide the basis for clinical studies of the drug. Methods The analgesic effects of Tuishao granule were evaluated by the writhing reaction of mice induced by glacial acetic acid and hot plate, while the anti-inflammatory effects were analyzed by using the mouse's ear swelling with xylene and the rats paw swelling with egg white.Result Compared with the model group and the control group, latent time was lengthened significantly and the pain threshold was increased, the frequency of writhing was reduced in mice by Tuishao granule, which showed that the paw swelling percentage of rats and ear swelling of mice were inhibited by Tuishao granule. Conclusion Tuishao granule had significant effects on anti-inflammatory and analgesic, which indicatedthat it had favorable effect on the treatment of inflammation and analgesic by anemopyretic cold.

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The anti-inflammatory and analgesic effects of Tuishao granule

doi: 10.3969/j.issn.1006-0111.2013.06.019

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通讯作者: 陈斌, [email protected]

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