Effect of combined therapy with alprostadil and mecobalamin injection on diabetic foot

WANG Chao

doi:10.3969/j.issn.1006-0111.2013.06.018

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Objective To explore the effect of combined therapy with alprostadil and mecobalamin injection on diabetic foot. Methods By simple randomization, the patients were divided into the observe group (accepted treatment of alprostadil and mecobalamin injection) and the control group(accepted treatment of salvia miltiorrhiza injection and mecobalamin tablets). The difference of effective rate, superficial peroneal sensory nerve conduction velocity and dorsalis pedis artery flow velocity were compared. Results ①The effective rate in the observed group was significantly higher than that in the control group(P<0.05); ② The superficial peroneal sensory nerve conduction velocity and dorsalis pedis artery flow velocity were significantly higher in the observed group than that of the control group after treatment(P<0.05). Conclusion Combined use of alprostadil and mecobalamin injection had a good effect in treatment of diabetic foot.

Effect of combined therapy with alprostadil and mecobalamin injection on diabetic foot

Endocrine Department, The Central Hospital of Taizhou, Taizhou 318000, China

Received Date: 2012-11-10

Rev Recd Date: 2013-04-25

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Abstract: Objective To explore the effect of combined therapy with alprostadil and mecobalamin injection on diabetic foot. Methods By simple randomization, the patients were divided into the observe group (accepted treatment of alprostadil and mecobalamin injection) and the control group(accepted treatment of salvia miltiorrhiza injection and mecobalamin tablets). The difference of effective rate, superficial peroneal sensory nerve conduction velocity and dorsalis pedis artery flow velocity were compared. Results ①The effective rate in the observed group was significantly higher than that in the control group(P<0.05); ② The superficial peroneal sensory nerve conduction velocity and dorsalis pedis artery flow velocity were significantly higher in the observed group than that of the control group after treatment(P<0.05). Conclusion Combined use of alprostadil and mecobalamin injection had a good effect in treatment of diabetic foot.

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Reference (7)

[1]	黄德斌, 李晓行, 邵芬, 等. 糖尿病足发生多重耐药菌感染的危险因素分析[J]. 中国全科医学, 2010, 15(5C):1689.
[2]	帅记焱, 徐江祥, 黄小红. 糖尿病足综合康复治疗的临床疗效观察[J]. 中华物理医学与康复杂志, 2012, 34(2):125.
[3]	刘良红, 付丹. 静脉微量泵应用前列地尔注射液治疗糖尿病下肢血管病变中不良反应的观察及护理对策[J]. 海峡药学, 2010, 22(6):246.
[4]	张晶, 张丹丹, 董群. 前列地尔脂微球注射液与糖脂平颗粒剂合用治疗糖尿病足临床疗效观察[J]. 中华中医药学刊, 2010, 28(6):1339.
[5]	郭世彪, 高淑霞, 张丽, 等. 前列地尔注射液治疗糖尿病并发症的疗效观察[J]. 山东医药, 51(37):58.
[6]	魏玉菊, 唐梅森. 复方丹参注射液与甲钴胺联合治疗糖尿病足47例[J]. 中国医药指南, 2010, 8(18):139.
[7]	谢宝强, 周青美. 甲钴胺与法舒地尔联合治疗糖尿病周围神经病变的疗效[J]. 中国老年学杂志, 2012, 32(1):949.

[1]	黄德斌, 李晓行, 邵芬, 等. 糖尿病足发生多重耐药菌感染的危险因素分析[J]. 中国全科医学, 2010, 15(5C):1689.
[2]	帅记焱, 徐江祥, 黄小红. 糖尿病足综合康复治疗的临床疗效观察[J]. 中华物理医学与康复杂志, 2012, 34(2):125.
[3]	刘良红, 付丹. 静脉微量泵应用前列地尔注射液治疗糖尿病下肢血管病变中不良反应的观察及护理对策[J]. 海峡药学, 2010, 22(6):246.
[4]	张晶, 张丹丹, 董群. 前列地尔脂微球注射液与糖脂平颗粒剂合用治疗糖尿病足临床疗效观察[J]. 中华中医药学刊, 2010, 28(6):1339.
[5]	郭世彪, 高淑霞, 张丽, 等. 前列地尔注射液治疗糖尿病并发症的疗效观察[J]. 山东医药, 51(37):58.
[6]	魏玉菊, 唐梅森. 复方丹参注射液与甲钴胺联合治疗糖尿病足47例[J]. 中国医药指南, 2010, 8(18):139.
[7]	谢宝强, 周青美. 甲钴胺与法舒地尔联合治疗糖尿病周围神经病变的疗效[J]. 中国老年学杂志, 2012, 32(1):949.

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Effect of combined therapy with alprostadil and mecobalamin injection on diabetic foot

doi: 10.3969/j.issn.1006-0111.2013.06.018

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通讯作者: 陈斌, [email protected]

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