Synthesis of 2-substitudephenoxy-5-benzyloxypyrimidines compounds

WEI Hai-yang; LIU Na; ZHOU You-jun; LV Jia-guo; ZHU Ju

doi:10.3969/j.issn.1006-0111.2013.06.013

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Volume 31 Issue 6

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2013 > 31(6): 446-447,469

WEI Hai-yang, LIU Na, ZHOU You-jun, LV Jia-guo, ZHU Ju. Synthesis of 2-substitudephenoxy-5-benzyloxypyrimidines compounds[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 446-447,469. doi: 10.3969/j.issn.1006-0111.2013.06.013

Citation:

WEI Hai-yang, LIU Na, ZHOU You-jun, LV Jia-guo, ZHU Ju. Synthesis of 2-substitudephenoxy-5-benzyloxypyrimidines compounds[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 446-447,469. doi: 10.3969/j.issn.1006-0111.2013.06.013

Synthesis of 2-substitudephenoxy-5-benzyloxypyrimidines compounds

doi: 10.3969/j.issn.1006-0111.2013.06.013

1.
Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Shanghai Sinch Pharmaceuticals Tech. Co., Ltd, Shanghai 200232, China
2.
Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2012-10-24
Rev Recd Date: 2013-04-25

Abstract

Objective To prepare 2-substitudephenoxy-5-benzyloxypyrimidines and 2-substitudephenoxy-5-hydroxypyrimidines which had not been reported. Methods The target compounds were prepared from 2-chlorine-5-hydroxypyrimidine through hydroxy protection, Williamsom reaction and reduction of benzyl group. Results The synthetic process provided a simple, easy diposal procedure and high overall yield. Fourteen new phenoxy pyrimidines compounds were prepared. Conclusions It was a new synthetic method which was easy to operate with moderate reaction conditions.
- 2-substitudephenoxy-5-benzyloxypyrimidines,
- 2-substitudephenoxy-5-hydroxypyrimidines,
- synthesis

References

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通讯作者: 陈斌, [email protected]

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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