Study on acceleration of wound healing by nano-fibers tunic carbonized hair loaded drug in rabbits

QIU Yan; LU Yi; DUAN Jing; MA Jing; SI Liang-hong; LIU Zi-xiu

doi:10.3969/j.issn.1006-0111.2013.06.011

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Objective To study the effect of the new type of hemostat for nano-fibers tunic carbonized hair loaded drug (NTCH) on skin wound healing in rabbits. Methods Bilateral round wounds were made on the backs of rabbits.There were six wounds in each rabbit, treated with medical gauze, absorbable gelatin sponge and NCTH. The effect of NCTH on the skin wound was evaluated by the index of closure time and healing rate. The variation of histopathological characteristics and the content of hydroxyproline in the wound tissue were observed. Results Animal experimental results showed that the NCTH hemostasis performance was better, also significantly reduced closure time, and improve healing rate. The hydroxyproline content in the wound tissue in the NCTH group on days 3, 7, 14 post-treatment was higher than that in medical gauze group (P<0.01).7 days post-treatment, the hydroxyproline content in the wound tissue in the NCTH group was higher than that in gelatin sponge group (P<0.05).On histology observation, 3 days and 7 days post-treatment, the numbers of collagenoblast was contrasted, there was statistical difference among the NCTH group, gelatin sponge group and medical gauze group(P<0.05, P<0.01). 3 days and 7 days post-treatment, the numbers of newly-born blood capillary was contrasted, there was statistical significance difference among the NCTH group, gelatin sponge group and medical gauze group(P<0.05, P<0.01). Conclusion The NCTH had significantly acceleration effect on the skin wound healing.

Study on acceleration of wound healing by nano-fibers tunic carbonized hair loaded drug in rabbits

Department of Pharmacy, No. 454 Hospital of PLA, Nanjing 210002, China

Received Date: 2013-01-14

Rev Recd Date: 2013-05-24

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Abstract: Objective To study the effect of the new type of hemostat for nano-fibers tunic carbonized hair loaded drug (NTCH) on skin wound healing in rabbits. Methods Bilateral round wounds were made on the backs of rabbits.There were six wounds in each rabbit, treated with medical gauze, absorbable gelatin sponge and NCTH. The effect of NCTH on the skin wound was evaluated by the index of closure time and healing rate. The variation of histopathological characteristics and the content of hydroxyproline in the wound tissue were observed. Results Animal experimental results showed that the NCTH hemostasis performance was better, also significantly reduced closure time, and improve healing rate. The hydroxyproline content in the wound tissue in the NCTH group on days 3, 7, 14 post-treatment was higher than that in medical gauze group (P<0.01).7 days post-treatment, the hydroxyproline content in the wound tissue in the NCTH group was higher than that in gelatin sponge group (P<0.05).On histology observation, 3 days and 7 days post-treatment, the numbers of collagenoblast was contrasted, there was statistical difference among the NCTH group, gelatin sponge group and medical gauze group(P<0.05, P<0.01). 3 days and 7 days post-treatment, the numbers of newly-born blood capillary was contrasted, there was statistical significance difference among the NCTH group, gelatin sponge group and medical gauze group(P<0.05, P<0.01). Conclusion The NCTH had significantly acceleration effect on the skin wound healing.

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Study on acceleration of wound healing by nano-fibers tunic carbonized hair loaded drug in rabbits

doi: 10.3969/j.issn.1006-0111.2013.06.011

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通讯作者: 陈斌, [email protected]

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