ZHANG Juan-juan, ZHU Quan-gang, ZHANG Li-chao. Effect of different density microneedle-roller on transdermal delivery of triamcinolone acetonide[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 415-417,461. doi: 10.3969/j.issn.1006-0111.2013.06.005
| Citation:
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ZHANG Juan-juan, ZHU Quan-gang, ZHANG Li-chao. Effect of different density microneedle-roller on transdermal delivery of triamcinolone acetonide[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 415-417,461. doi: 10.3969/j.issn.1006-0111.2013.06.005
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Effect of different density microneedle-roller on transdermal delivery of triamcinolone acetonide
- 1.
Graduate school of Ningxia Medical University, Ningxia Yinchuan 750004, China;Department of Pharmacy, Shanghai Seventh People Hospital, Shanghai 200137, China
- 2.
Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
- 3.
Department of Pharmacy, Shanghai Seventh People Hospital, Shanghai 200137, China
- Received Date: 2013-03-22
- Rev Recd Date:
2013-05-14
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Abstract
Objective To study the effects of different density microneedle-roller arrays on transdermal delivery of triamcinolone acetonide. Methods The in vitro permeation characteristics through isolated nude mouse skin were studied by modified Franz diffusion cells. Levels in the receptor solution of the control group, the 192 needles microneedle rooler group and the 540 needles microneedle rooler group were measured by HPLC at 2、4、6、8、10 and 12 h, and sampling volume was 0.2 ml. The accumulative penetration amount were counted and the level of triamcinolone acetonide in skin were determined. Plasma concentrations of triamcinolone acetonide and skin volume were measured 2 hours later after administration by HPLC to observe the penetration of triamcinolone acetonide in vivo. Results Different density microneedle-roller could promote the transdermal delivery of triamcinolone acetonide respectively. Transdermal experiment results showed that the cumulative infiltration volume of 192 needles group was about 1.3 times of the control samples, and 540 needles was 2.2 times. Accordingly, skin retention volume were1.9times and 2.8 times of the control group respectively. In vivo results showed that skin retention volume were 2.1 times and 2.3 times of control group, while triamcinolone acetonide in plasma were 1.3 times and 1.4 times of control group. Conclusion Microneedles could effectively promote the skin permeability and deposition of triamcinolone acetonide, and triamcinolone acetonide in plasma was increased at the same time. The promoting of different density was diverse.
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